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Ephrin type-A receptor 4
go.drugbank.com/bio_entities/BE0009438TargetHumansIn the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. … In addition to its role in axonal guidance plays a role in synaptic plasticity.
Polypeptides: Ephrin type-A receptor 4Acyl-coenzyme A thioesterase 1
go.drugbank.com/bio_entities/BE0016368EnzymeHumansCatalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels.
Polypeptides: Acyl-coenzyme A thioesterase 1Synonyms: Palmitoyl-coenzyme A thioesterase, Inducible cytosolic acyl-coenzyme A thioester hydrolasePonatinib
go.drugbank.com/drugs/DB08901ApprovedInvestigationalPonatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic IndexProducts: ICLUSIG® 15 MG TABLETAS RECUBIERTAS, ICLUSIG TABLET 45 MGPindolol
go.drugbank.com/drugs/DB00960ApprovedInvestigationalPindolol is a first generation non-selective beta blocker used in the treatment of hypertension. … [A231064] Pindolol was granted FDA approval on 3 September 1982.[L32348]
Synonyms: 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)-propan-2-ol, 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-olInternational brands: Blockin L, Blocklin LMagnesium salicylate
go.drugbank.com/drugs/DB01397Approved), effective pain relief is often found with a half dosage, with reduced anti-inflammatory results. … Magnesium salicylate is a non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain. It is available in several over-the-counter (OTC) formulations.
Categories: Non COX-2 selective NSAIDSProducts: Back-ese M Tablets 325 mg, Back-ese M Tab 325mgLacidipine
go.drugbank.com/drugs/DB09236ApprovedIt is available as once-daily oral tablets containing 2 or 4 mg of the active compound commonly marketed as Lacipil or Motens. It is not currently FDA-approved. … In randomised, well-controlled trials, administration of daily single-dose lacidipine ranging from 2-6 mg demonstrated comparable antihypertensive efficacy similar to that of other long-acting dihydropyridine
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: LACIPIL TABLET 4 mg, LACIPIL 4 MG FILM KAPLI TABLET, 14 ADETOryctolagus cuniculus hair
go.drugbank.com/drugs/DB10898ApprovedEuropean rabbit hair is used in allergenic testing.
Synonyms: European rabbit hair extractMilnacipran
go.drugbank.com/drugs/DB04896ApprovedInvestigationalNevertheless, milnacipran demonstrates a somewhat unique characteristic among SNRIs to elicit a relatively balanced reuptake inhibition of both serotonin and noradrenaline, with a somewhat increased preference … (BACE-1), which has investigationally been associated with β-amyloid plaque formation - making the agent a possible course of treatment for Alzheimer's disease [A175957].
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: Ixel 25 mg - Kapseln, Ixel 50 mg - KapselnAztreonam
go.drugbank.com/drugs/DB00355ApprovedInvestigationalIt may cause a superinfection with gram-positive organisms. … A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum.
Synonyms: 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl) -2- {[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino} -2- oxoethylidene]amino}oxy)-2-methylpropanoic acid, (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acidCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingDecitabine
go.drugbank.com/drugs/DB01262ApprovedInvestigational[A2263, A2264, A2265, A215317, L14962] Decitabine was developed by MGI Pharma/SuperGen Inc. and was approved by the FDA for the treatment of MDS on February 5, 2006. … Further mutations leading to increased proliferation of cancerous cells can eventually lead to secondary acute myeloid leukemia, which has a poor prognosis.
Synonyms: 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one, 5-aza-2'-deoxycytidineCategories: Heterocyclic Compounds, 1-Ring