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Secretin human
go.drugbank.com/drugs/DB09532ApprovedInvestigationalHuman secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. The hormone is produced from the enterochromaffin cells in the duodenum in response to the duodenal content with the pH l...
Remestemcel-L
go.drugbank.com/drugs/DB13973ApprovedInvestigationalWithdrawnRemestemcel-L is a third-party, off-the-shelf suspension of ex-vivo cultured adult human mesenchymal stem cells intended for intravenous infusion. The mesenchymal stem cells are derived from the bone marrow of unrelated and human leukocy...
Cetilistat
go.drugbank.com/drugs/DB06586InvestigationalCetilistat is a novel inhibitor of pancreatic lipase being developed by Alizyme for the treatment of obesity and associated co-morbidities, including type 2 diabetes.
ATX-101
go.drugbank.com/drugs/DB05780InvestigationalThis includes treatment of superficial lipomas (benign tumors of soft tissue composed of mature fat cells), fat deposits in the submental region of the face/neck, and localized fat deposits in other parts
Autologous cultured chondrocytes
go.drugbank.com/drugs/DB10997ApprovedInvestigationalIt has been used since 1995 as Carticel and gained biologic license in 1997. The surgical implantation was first performed in Sweden.
Adrafinil
go.drugbank.com/drugs/DB08925ApprovedWithdrawnIt is also been used off-label to prevent fatigue or falling asleep for extended periods of time. Adrafinil does not currently have FDA approval and is thus unregulated in the United States.
Lymecycline
go.drugbank.com/drugs/DB00256ApprovedInvestigationalWithdrawn[L13880,L13883] It has been proven a cost-effective alternative to treatment with [minocycline] with comparable safety and efficacy.[A203255] Lymecycline was initially discovered in 1961.
Nilutamide
go.drugbank.com/drugs/DB00665ApprovedInvestigationalTo date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.
Valerian
go.drugbank.com/drugs/DB13196ApprovedValerian has been used in the treatment of conditions including sleep disorders, anxiety, attention deficit-hyperactivity disorder (ADHD) and joint pain.
Ketamine
go.drugbank.com/drugs/DB01221ApprovedInvestigationalVet approvedIt was FDA approved in 1970, and from there, it has been used as an anesthetic for children or patients undergoing minor surgeries but mainly for veterinary purposes.[L1332]