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Abciximab
go.drugbank.com/drugs/DB00054ApprovedWithdrawnAbciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules … It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells.
Categories: Amino Acids, Peptides, and Proteins, Blood and Blood Forming OrgansTeplizumab
go.drugbank.com/drugs/DB06606ApprovedInvestigational[A241490] Anti-CD3 therapy has traditionally been used to prevent graft-versus-host-disease in organ transplantation but more recently has been explored to prolong the onset of (T1D) in high-risk patients … [L44091] Fc-receptors can bind to the "tail-end" anti-CD3 antibodies in an antigen-non-specific manner and lead to severe adverse effects related to cytokine release syndrome (CRS).
Categories: Alimentary Tract and Metabolism, Amino Acids, Peptides, and ProteinsRamelteon
go.drugbank.com/drugs/DB00980ApprovedInvestigationalRamelteon has not been shown to produce dependence and has shown no potential for abuse. … Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN).
Categories: Hypnotics and SedativesLindane
go.drugbank.com/drugs/DB00431ApprovedWithdrawnIn Canada, Lindane is not recommmended as a first-line therapy due to reports of resistance, neurotoxicity, and bone marrow suppression, but has been approved by the FDA as a second-line therapy for topical … Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment.
Categories: Scabicides, Insecticides and Repellents, Antiparasitic Products, Insecticides and RepellentsCalcium citrate
go.drugbank.com/drugs/DB11093ApprovedInvestigationalCalcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements.
Mixtures: Calcium and Magnesium Citrate and Vitamin D 250mg/125mg/200iu, Cal-mag (one To One) With Potass & ZincCategories: Diet, Food, and Nutrition, Alimentary Tract and MetabolismSodium glycerophosphate
go.drugbank.com/drugs/DB09561ApprovedIt is used clinically to treat or prevent low phosphate levels [FDA Label]. Glycerophosphate is hydrolyzed to inorganic phosphate and glycerol in the body [A32667]. … The extent of this reaction is dependent on the activity of serum alkaline phosphatases.
Mixtures: Vitamin and Mineral Supplement - Liq, Hemarexin Liquid and Drinkable AmpoulesCategories: Blood and Blood Forming Organs, Blood Substitutes and Perfusion SolutionsCysteamine
go.drugbank.com/drugs/DB00847ApprovedInvestigational[L15606] Cysteamine eye drops are a practical and effective option for those affected by ocular cystinosis. … A defect in cystinosin function is followed by cystine accumulation throughout the body, especially the eyes and kidneys.
Categories: Amino Acids and Derivatives, Alimentary Tract and MetabolismTestosterone enanthate
go.drugbank.com/drugs/DB13944ApprovedInvestigationalThis slow release is achieved by the presence of the enanthate ester functional group attached to the testosterone molecule. … Testosterone enanthate is an esterified variant of testosterone that comes as an injectable compound with a slow-release rate.
Mixtures: Neo Pause InjectionCategories: Testosterone and derivatives, Hormones, Hormone Substitutes, and Hormone AntagonistsEfanesoctocog alfa
go.drugbank.com/drugs/DB16662ApprovedInvestigationalEndogenous VWF protects FVIII from degradation but also sets a half-life of approximately 15 to 19 h. … [A257464] Efanesoctocog alfa was designed to have an extended half-life, and to surpass the half-life ceiling to which other forms of recombinant FVIII are subjected due to their association with von Willebrand
Categories: Amino Acids, Peptides, and ProteinsWU-CART-007
go.drugbank.com/drugs/DB18617InvestigationalWU-CART-007 consists of allogeneic, fratricide-resistant genetically modified T cells transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human CD7.
Synonyms: an allogeneic, fratricide-resistant genetically modified T cell transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human CD7