Sodium glycerophosphate

Identification

Name
Sodium glycerophosphate
Accession Number
DB09561
Description

Sodium glycerophosphate is one of several glycerophosphate salts. It is used clinically to treat or prevent low phosphate levels Label. Glycerophosphate is hydrolyzed to inorganic phosphate and glycerol in the body 1. The extent of this reaction is dependent on the activity of serum alkaline phosphatases.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 216.036
Monoisotopic: 215.9775635
Chemical Formula
C3H7Na2O6P
Synonyms
  • Disodium glycerol phosphate
  • Sodium glycerophosphate anhydrous

Pharmacology

Indication

Sodium glycerophosphate is indicated for use as a source of phosphate in total parenteral nutrition Label. It is used in combination with amino acids, dextrose, lipid emulsions, and other electrolytes.

Associated Therapies
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics

Glycerophosphate acts as a source of inorganic phosphate through hydrolysis 1.

Mechanism of action

Sodium glycerophosphate acts as a donor of inorganic phosphate 1. See Monopotassium phosphate for a description of phosphate's role in the body.

Absorption

Peak serum phosphate concentration is reached in 4h 1.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Glycerophosphate is hydrolyzed to form inorganic phosphate 1. The extent of this reaction is dependent on serum alkaline phosphatase activity.

Route of elimination

Inorganic phosphate produced is eliminated in the urine 1. There may be a very small amount of glycerophosphate excreted in the urine unchanged.

Half-life

Inorganic phosphate has a half-life of elimination of 2.06h 1.

Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Sodium glycerophosphate hydrateRCS9EQ01V455073-41-1OFNNKPAERNWEDD-UHFFFAOYSA-L
Active Moieties
NameKindUNIICASInChI Key
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
International/Other Brands
Glycophos (Fresenius Kabi Norge)
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
GlycophosInjection, solution216 mg/1mLIntravenousFresenius Kabi USA, LLC2013-05-13Not applicableUS flag
Additional Data Available
  • Application Number
    Application Number
    Available for Purchase

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code
    Available for Purchase

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Hemarexin Liquid and Drinkable AmpoulesSodium glycerophosphate (3.65 mg) + Riboflavin 5'-phosphate sodium (1 mg) + Nicotinamide (10 mg) + Thiamine (1 mg)LiquidOralSabex Inc1997-08-192009-11-26Canada flag
KabivenSodium glycerophosphate (147 mg/100mL) + Alanine (467 mg/100mL) + Arginine (330 mg/100mL) + Aspartic acid (99 mg/100mL) + Calcium chloride dihydrate (29 mg/100mL) + D-glucose monohydrate (9.8 g/100mL) + Glutamic acid (164 mg/100mL) + Glycine (231 mg/100mL) + Histidine (199 mg/100mL) + Isoleucine (164 mg/100mL) + L-Lysine hydrochloride (263 mg/100mL) + Leucine (231 mg/100mL) + Magnesium sulfate heptahydrate (96 mg/100mL) + Methionine (164 mg/100mL) + Phenylalanine (231 mg/100mL) + Potassium chloride (174 mg/100mL) + Proline (199 mg/100mL) + Serine (131 mg/100mL) + Sodium acetate trihydrate (239 mg/100mL) + Soybean oil (3.9 g/100mL) + Threonine (164 mg/100mL) + Tryptophan (55 mg/100mL) + Tyrosine (6.7 mg/100mL) + Valine (213 mg/100mL)Injection, emulsionIntravenousFresenius Kabi USA, LLC2014-08-25Not applicableUS flag
Olimel 3.3% ESodium glycerophosphate (3.67 g) + Alanine (4.76 g) + Arginine (3.22 g) + Aspartic acid (0.95 g) + Calcium chloride (0.52 g) + Dextrose, unspecified form (126.5 g) + Glutamic acid (1.64 g) + Glycine (2.28 g) + Histidine (1.96 g) + Isoleucine (1.64 g) + L-Lysine acetate (2.59 g) + Leucine (2.28 g) + Magnesium chloride (0.81 g) + Methionine (1.64 g) + Olive oil (32 g) + Phenylalanine (2.28 g) + Potassium chloride (2.24 g) + Proline (1.96 g) + Serine (1.30 g) + Sodium acetate trihydrate (1.50 g) + Soybean oil (8 g) + Threonine (1.64 g) + Tryptophan (0.55 g) + Tyrosine (0.08 g) + Valine (2.1 g)EmulsionIntravenousBaxter LaboratoriesNot applicableNot applicableCanada flag
Olimel 4.4% ESodium glycerophosphate (3.67 g) + Alanine (6.41 g) + Arginine (4.34 g) + Aspartic acid (1.28 g) + Calcium chloride (0.52 g) + Dextrose, unspecified form (154 g) + Glutamic acid (2.21 g) + Glycine (3.07 g) + Histidine (2.64 g) + Isoleucine (2.21 g) + L-Lysine acetate (3.48 g) + Leucine (3.07 g) + Magnesium chloride (0.81 g) + Methionine (2.21 g) + Olive oil (32 g) + Phenylalanine (3.07 g) + Potassium chloride (2.24 g) + Proline (2.64 g) + Serine (1.75 g) + Sodium acetate trihydrate (1.50 g) + Soybean oil (8 g) + Threonine (2.21 g) + Tryptophan (0.74 g) + Tyrosine (0.11 g) + Valine (2.83 g)EmulsionIntravenousBaxter Laboratories2011-02-26Not applicableCanada flag
Olimel 5.7% ESodium glycerophosphate (3.67 g) + Alanine (8.24 g) + Arginine (5.58 g) + Aspartic acid (1.65 g) + Calcium chloride (0.52 g) + Dextrose, unspecified form (121 g) + Glutamic acid (2.84 g) + Glycine (3.95 g) + Histidine (3.40 g) + Isoleucine (2.84 g) + L-Lysine acetate (4.48 g) + Leucine (3.95 g) + Magnesium chloride (0.81 g) + Methionine (2.84 g) + Olive oil (32 g) + Phenylalanine (3.95 g) + Potassium chloride (2.24 g) + Proline (3.40 g) + Serine (2.25 g) + Sodium acetate trihydrate (1.50 g) + Soybean oil (8 g) + Threonine (2.84 g) + Tryptophan (0.95 g) + Tyrosine (0.15 g) + Valine (3.64 g)EmulsionIntravenousBaxter Laboratories2011-01-19Not applicableCanada flag
Olimel 7.6% ESodium glycerophosphate (3.67 g) + Alanine (10.99 g) + Arginine (7.44 g) + Aspartic acid (2.2 g) + Calcium chloride (0.52 g) + Dextrose, unspecified form (80.67 g) + Glutamic acid (3.79 g) + Glycine (5.26 g) + Histidine (4.53 g) + Isoleucine (3.79 g) + L-Lysine acetate (5.97 g) + Leucine (5.26 g) + Magnesium chloride (0.81 g) + Methionine (3.79 g) + Olive oil (28 g) + Phenylalanine (5.26 g) + Potassium chloride (2.24 g) + Proline (4.53 g) + Serine (3 g) + Sodium acetate trihydrate (1.5 g) + Soybean oil (7 g) + Threonine (3.79 g) + Tryptophan (1.26 g) + Tyrosine (0.2 g) + Valine (4.86 g)EmulsionIntravenousBaxter Laboratories2018-10-25Not applicableCanada flag
PerikabivenSodium glycerophosphate (105 mg/100mL) + Alanine (333 mg/100mL) + Arginine (235 mg/100mL) + Aspartic acid (71 mg/100mL) + Calcium chloride dihydrate (20 mg/100mL) + D-glucose monohydrate (6.8 g/100mL) + Glutamic acid (116 mg/100mL) + Glycine (164 mg/100mL) + Histidine (141 mg/100mL) + Isoleucine (116 mg/100mL) + L-Lysine hydrochloride (187 mg/100mL) + Leucine (164 mg/100mL) + Magnesium sulfate heptahydrate (68 mg/100mL) + Methionine (116 mg/100mL) + Phenylalanine (164 mg/100mL) + Potassium chloride (174 mg/100mL) + Proline (141 mg/100mL) + Serine (94 mg/100mL) + Sodium acetate trihydrate (170 mg/100mL) + Soybean oil (3.5 g/100mL) + Threonine (116 mg/100mL) + Tryptophan (40 mg/100mL) + Tyrosine (4.8 mg/100mL) + Valine (152 mg/100mL)Injection, emulsionIntravenousFresenius Kabi USA, LLC2014-08-25Not applicableUS flag
Periolimel 2.5% ESodium glycerophosphate (1.91 g) + Alanine (3.66 g) + Arginine (2.48 g) + Aspartic acid (0.73 g) + Calcium chloride (0.30 g) + Dextrose, unspecified form (82.50 g) + Glutamic acid (1.26 g) + Glycine (1.76 g) + Histidine (1.51 g) + Isoleucine (1.26 g) + L-Lysine acetate (1.99 g) + Leucine (1.76 g) + Magnesium chloride (0.45 g) + Methionine (1.26 g) + Olive oil (24 g) + Phenylalanine (1.76 g) + Potassium chloride (1.19 g) + Proline (1.51 g) + Serine (1.0 g) + Sodium acetate trihydrate (1.16 g) + Soybean oil (6 g) + Threonine (1.26 g) + Tryptophan (0.42 g) + Tyrosine (0.06 g) + Valine (1.62 g)EmulsionIntravenousBaxter Laboratories2011-02-28Not applicableCanada flag
SmofkabivenSodium glycerophosphate (0.21 g) + Alanine (0.71 g) + Arginine (0.61 g) + Calcium chloride (0.028 g) + Dextrose, unspecified form (12.7 g) + Fish oil (0.57 g) + Glycine (0.56 g) + Histidine (0.15 g) + Isoleucine (0.25 g) + L-Lysine (0.34 g) + Leucine (0.38 g) + Magnesium sulfate (0.061 g) + Medium-chain triglycerides (1.14 g) + Methionine (0.22 g) + Nitrogen (0.8 g) + Olive oil (0.95 g) + Phenylalanine (0.26 g) + Potassium chloride (0.23 g) + Proline (0.57 g) + Serine (0.33 g) + Sodium acetate trihydrate (0.17 g) + Soybean oil (1.14 g) + Taurine (0.05 g) + Threonine (0.22 g) + Tryptophan (0.10 g) + Tyrosine (0.02 g) + Valine (0.31 g) + Zinc sulfate heptahydrate (0.00066 g)EmulsionIntravenousFresenius Kabi2015-09-15Not applicableCanada flag
Smofkabiven Extra NitrogenSodium glycerophosphate (0.23 g) + Alanine (0.92 g) + Arginine (0.79 g) + Calcium chloride (0.028 g) + Dextrose, unspecified form (8.5 g) + Fish oil (0.43 g) + Glycine (0.72 g) + Histidine (0.2 g) + Isoleucine (0.33 g) + L-Lysine (0.43 g) + Leucine (0.48 g) + Magnesium sulfate (0.061 g) + Medium-chain triglycerides (0.87 g) + Methionine (0.28 g) + Nitrogen (1.1 g) + Olive oil (0.72 g) + Phenylalanine (0.33 g) + Potassium chloride (0.23 g) + Proline (0.73 g) + Serine (0.43 g) + Sodium acetate (0.16 g) + Soybean oil (0.87 g) + Taurine (0.065 g) + Threonine (0.29 g) + Tryptophan (0.13 g) + Tyrosine (0.026 g) + Valine (0.41 g) + Zinc sulfate heptahydrate (0.00066 g)EmulsionIntravenousFresenius KabiNot applicableNot applicableCanada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
GlycophosSodium glycerophosphate (216 mg/1mL)Injection, solutionIntravenousFresenius Kabi USA, LLC2013-05-13Not applicableUS flag

Categories

ATC Codes
B05XA14 — Sodium glycerophosphate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as glycerophosphates. These are compounds containing a glycerol linked to a phosphate group.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Glycerophospholipids
Sub Class
Glycerophosphates
Direct Parent
Glycerophosphates
Alternative Parents
Alkyl phosphates / Secondary alcohols / 1,2-diols / Primary alcohols / Organic sodium salts / Organic oxides / Hydrocarbon derivatives
Substituents
1,2-diol / Alcohol / Aliphatic acyclic compound / Alkyl phosphate / Hydrocarbon derivative / Organic alkali metal salt / Organic oxide / Organic oxygen compound / Organic phosphoric acid derivative / Organic salt
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
Not Available

Chemical Identifiers

UNII
YP1H63LJ2K
CAS number
1334-74-3
InChI Key
GEKBIENFFVFKRG-UHFFFAOYSA-L
InChI
InChI=1S/C3H9O6P.2Na/c4-1-3(5)2-9-10(6,7)8;;/h3-5H,1-2H2,(H2,6,7,8);;/q;2*+1/p-2
IUPAC Name
disodium 3-(phosphonooxy)propane-1,2-diol
SMILES
[Na+].[Na+].OCC(O)COP([O-])([O-])=O

References

General References
  1. Topp H, Hochfeld O, Bark S, Grossmann M, Joukhadar C, Westphal M, Straatsma H, Rothenburger M: Glycerophosphate is interchangeable with inorganic phosphate in terms of safety and serum pharmacokinetics. Pharmacology. 2011;88(3-4):193-200. doi: 10.1159/000331341. Epub 2011 Oct 4. [PubMed:21986180]
PubChem Compound
22251426
PubChem Substance
347827880
ChemSpider
14071
RxNav
1595589
ChEMBL
CHEMBL3040581
FDA label
Download (806 KB)
MSDS
Download (46.7 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Not Yet RecruitingDiagnosticHypophosphatemia1
4TerminatedSupportive CareCancer-related Malnutrition1
4TerminatedSupportive CareIllness, Critical1
4WithdrawnSupportive CareMalnutrition1
3CompletedTreatmentGeneral Surgery / Parenteral Feeding1
3CompletedTreatmentGeneral Surgery / Parenteral Nutrition1
3CompletedTreatmentParents2
3TerminatedTreatmentMalignant Neoplasm of Pancreas1
Not AvailableRecruitingTreatmentMalignancies, Hematologic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solutionIntravenous2.5 g/500mL
SolutionIntravenous2.55 g/L
SolutionIntravenous0.61 g/L
SolutionIntravenous1.79 g/L
SolutionIntravenous1.66 g/L
EmulsionParenteral3.99 g/1085ml
EmulsionParenteral2.05 g/1085ml
Injection, solutionIntramuscular100 mg/2ml
SyrupOral10 mg/ml
TabletOral40 MG
Injection, solutionIntravenous216 mg/1mL
Injection, solution, concentrateIntravenous216 mg/1mL
Injection, solution, concentrateIntravenous6 g/20ml
Injection, solutionIntravenous216 mg/mL
SolutionIntravenous216 mg
Injection, emulsionIntravenous
Injection, emulsionIntravenous467 mg/100mL
InjectionIntravenous110 g
InjectionIntravenous165 g
InjectionIntravenous220 g
InjectionIntravenous275 g
InjectionIntravenous107 g
InjectionIntravenous143 g
InjectionIntravenous178 g
SolutionIntravenous16 g/L
Injection, emulsionParenteral2.33 g
Injection, emulsionIntravenous1.03 g
Injection, emulsionIntravenous1.83 g
EmulsionIntravenous1.83 g
InjectionIntravenous1.03 g
Injection, emulsionIntravenous1.6 g/100mL
Injection, emulsion; injection, solutionIntravenous3.2 g/100mL
Injection, emulsionIntravenous12 g/1500ml
Injection, emulsionIntravenous32 g/1000ml
Injection, emulsionIntravenous0.52 g/1000ml
Injection, emulsionIntravenous0.42 g/1000ml
Injection, emulsionIntravenous1.6 g
InjectionIntravenous2.27 g/l
InjectionIntravenous4.12 g/l
SolutionIntravenous7.14 g
SolutionIntravenous9.52 g
SolutionIntravenous11.9 g
EmulsionIntravenous6.41 g
EmulsionIntravenous9.61 g
EmulsionIntravenous12.82 g
Injection, emulsionIntravenous6.41 g/1000ml
EmulsionIntravenous4 g
Injection, emulsionIntravenous8.24 g/1000ml
EmulsionParenteral1.26 g
EmulsionIntravenous
EmulsionIntravenous3 g
Injection, emulsionIntravenous3.66 g
Injection, emulsionIntravenous5.5 g
Injection, emulsionIntravenous7.33 g
Injection, emulsionIntravenous9.16 g
Injection, emulsionIntravenous3.66 g/1000ml
SolutionIntravenous3.2 g/100mL
SolutionIntravenous1.6 g/100mL
EmulsionParenteral1.6 g/l
EmulsionParenteral0.61 g/l
EmulsionParenteral440 mg
Injection, emulsionIntravenous4.4 g/1000ml
EmulsionParenteral3.1 g
Injection, emulsionIntravenous7.1 g/1000ml
EmulsionParenteral50 g
EmulsionParenteral0.28 g
EmulsionParenteral0.18 g
LiquidOral
EmulsionParenteral2.24 g
EmulsionParenteral4.34 g
EmulsionParenteral3.95 g
EmulsionParenteral28 g/1000ml
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
water solubilitySolubleMSDS
Predicted Properties
PropertyValueSource
Water Solubility81.5 mg/mLALOGPS
logP-1.4ALOGPS
logP-2ChemAxon
logS-0.42ALOGPS
pKa (Strongest Acidic)1.51ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area112.88 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity29.15 m3·mol-1ChemAxon
Polarizability12.87 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on November 30, 2015 12:10 / Updated on June 12, 2020 10:52

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