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Displaying results 2281 - 2290 of 10000 in total
  1. Drug

    Fexinidazole

    go.drugbank.com/drugs/DB12265
    Approved

    [A237555, A237560] Fexinidazole received a positive opinion from the European Medicines Agency (EMA) in November 2018 and was approved by the FDA on July 16, 2021. … Human African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by _T. brucei gambiense_ and _T. brucei rhodesiense_, remains a moderate risk (>1/10,000 inhabitants per

    Categories: MATE 2-K Inhibitors, MATE 1 Inhibitors
  2. Drug

    Epofolate

    go.drugbank.com/drugs/DB12266
    Investigational

    Epofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to selectively target folate receptor expressing cancer cells. … and neutropenia appear to have been less frequent and less severe as compared to epothilones.

    Categories: Cytochrome P-450 CYP3A Inhibitors, Heterocyclic Compounds, 2-Ring
  3. Drug

    Aducanumab

    go.drugbank.com/drugs/DB12274
    ApprovedInvestigational

    in amyloid-β plaques. … Aducanumab, or BIIB037, is a monoclonal IgG1 antibody that targets extracellular amyloid-β plaques in the brain; similar to [gantenerumab], [bapineuzumab] and [solanezumab].

  4. Drug

    AZD-5423

    go.drugbank.com/drugs/DB12280
    Investigational

    AZD5423 has been used in trials studying the basic science and treatment of Asthma, Bioavailability and AUC, and Chronic Obstructive Pulmonary Disease (COPD).

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  5. Drug

    Darexaban

    go.drugbank.com/drugs/DB12289
    Investigational

    Darexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others.

    Categories: Heterocyclic Compounds, 1-Ring
  6. Drug

    5-Hydroxymethylfurfural

    go.drugbank.com/drugs/DB12298
    Investigational

    Aes-103 has been used in trials studying the treatment and prevention of Hypoxia, Anemia, Sickle Cell, and Sickle Cell Disease.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-(hydroxymethyl)-2-furaldehyde, 5-(Hydroxymethyl)-2-furfural
  7. Drug

    Bavisant

    go.drugbank.com/drugs/DB12299
    Investigational

    Bavisant has been used in trials studying the basic science and treatment of Alcoholism, Pharmacokinetics, Drug Interactions, Attention Deficit Hyperactivity Disorder, and Attention Deficit Disorders With Hyperactivity.

    Categories: Heterocyclic Compounds, 1-Ring
  8. Drug

    Radotinib

    go.drugbank.com/drugs/DB12323
    Investigational

    Radotinib is under investigation for the treatment of Leukemia, Myelogenous, Chronic, BCR-ABL Positive.

    Categories: Heterocyclic Compounds, 1-Ring
  9. Drug

    Aticaprant

    go.drugbank.com/drugs/DB12341
    Investigational

    Aticaprant has been used in trials studying the health services research and basic science of Anxiety Disorders and Alcohol Dependence.

    Synonyms: BENZAMIDE, 4-(4-(((2S)-2-(3,5-DIMETHYLPHENYL)-1-PYRROLIDINYL)METHYL)PHENOXY)-3-FLUORO-Categories: Heterocyclic Compounds, 1-Ring
  10. Drug

    Bizelesin

    go.drugbank.com/drugs/DB12352
    Investigational

    Bizelesin has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring