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Diethylcarbamazine
go.drugbank.com/drugs/DB00711ApprovedInvestigationalVet approvedWithdrawnAn anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
Ublituximab
go.drugbank.com/drugs/DB11850ApprovedInvestigational(ADCC), mediated by interactions between an antibody and Fcγ receptors on natural killer cells or macrophages. … [L44508] The next year, June 2023, ublituximab was also approved by the EMA for the treatment of relapsing forms of multiple sclerosis in adult patients.[L47486]
Rexin G
go.drugbank.com/drugs/DB16450InvestigationalRexin-G is a tumor-targeted, injectable retroviral vector carrying a mutant form of the cyclin G1 gene. … It is under development by Epeius Biotechnologies for the potential treatment of metastatic cancer. It is also being investigated for preventing SARSCOV-2 viral entry.
Vortioxetine
go.drugbank.com/drugs/DB09068ApprovedInvestigationalreceptor, an agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. … role in the efficacy of SRIs in treating depression.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeErlotinib
go.drugbank.com/drugs/DB00530ApprovedInvestigationalof patients with idiopathic myelofibrosis or essential thrombocythemia. … Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer
Ocrelizumab
go.drugbank.com/drugs/DB11988ApprovedInvestigationalOcrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). … In clinical trials of patients with relapsing forms of MS, treatment with ocrelizumab resulted in reduced relapse rates and reduced worsening of disability compared to [interferon beta-1a].
Bovine type I collagen
go.drugbank.com/drugs/DB10771ApprovedInvestigationalExcellagen, a topical gel of bovine type I collagen, is used in the management of wounds including: partial and full- thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular … It plays a vital role in cell growth, differentiation, attachment, and migration [L2481].
Polidocanol
go.drugbank.com/drugs/DB06811ApprovedInvestigationalThe formula for Polidocanol has the structural formula C12H25(OCH2CH2)nOH, a mean extent of polymerization (n) of approximately 9 and a mean molecular weight of approximately 600. … Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower
Categories: Compounds used in a research, industrial, or household settingPamapimod
go.drugbank.com/drugs/DB19169InvestigationalPamapimod is under investigation in clinical trial NCT05659459 (The KIN-FAST Trial (KIN001 for Accelerated Symptoms Termination) in Non Hospitalized Patients Infected With Sars-cov-2).
Synonyms: 6-(2,4-Difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxyethyl)propyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-oneAminophenazone
go.drugbank.com/drugs/DB01424ApprovedWithdrawnThe FDA suspended the use of aminophenazone due to its association with agranulocytosis, a life-threatening side effect.[A254242,L43942] … Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties that carries a risk of agranulocytosis.
Categories: Non COX-2 selective NSAIDS, Anti-Inflammatory Agents, Non-SteroidalSynonyms: 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one, 4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one