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Desipramine
go.drugbank.com/drugs/DB01151ApprovedSecondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation.
Synonyms: N-(3-methylaminopropyl)iminobibenzylProducts: PMS-desipramine - Tab 100mg, PMS Desipramine Hydro Tab 50mgVenlafaxine
go.drugbank.com/drugs/DB00285ApprovedInvestigational[A252065] Venlafaxine has been used as a first-line treatment for MDD, GAD, social anxiety disorder, and panic disorder in Canada for many years. … It was also considered a second-line treatment for obsessive-compulsive disorder (OCD).
Products: PMS-venlafaxine XR, Venlafaxine HCL ERPramipexole
go.drugbank.com/drugs/DB00413ApprovedInvestigationalIt was first approved by the FDA in 1997 [L5882]. … The prevalence of Parkinson's Disease worldwide has increased from approximately 2.5 million in 1990 to about 6.1 million in 2016 [A176861].
Mixtures: Mirapex ER, Mirapex ERSynonyms: (S)-N 6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diaminePropranolol
go.drugbank.com/drugs/DB00571ApprovedInvestigational[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904] … Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.
Products: Propranolol HCL ER, Propranolol hcl ERDimenhydrinate
go.drugbank.com/drugs/DB00985ApprovedInvestigationalDimehydrinate was first described in the literature in 1949,[A233120] and patented in 1950. … [L32995] Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery.
Synonyms: N,N-dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinate, 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)Products: Pac-Kit Motion Sickness, PMS-dimenhydrinate Tab 50mgTopotecan
go.drugbank.com/drugs/DB01030ApprovedInvestigationalAn antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.
Products: PMS-topotecan, Topotecan Hikma 1 mg Pulver für ein Konzentrat zur Herstellung einer InfusionslösungFlutamide
go.drugbank.com/drugs/DB00499ApprovedInvestigationalAn antiandrogen with about the same potency as cyproterone in rodent and canine species.
Products: PMS-flutamide, FLUTAMIDE EGTizanidine
go.drugbank.com/drugs/DB00697ApprovedInvestigationalInitially approved by the FDA in 1996, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons … Regardless of the cause, muscle spasticity can be an extremely painful and debilitating condition.
Products: Pal-tizanidine, Comfort Pac with TizanidineMethotrexate
go.drugbank.com/drugs/DB00563ApprovedInvestigational[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients … [L7180] Methotrexate was granted FDA approval on 7 December 1953.[L7198]
Synonyms: 4-amino-N(10)-methylpteroylglutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acidProducts: PMS-methotrexate, PMS-methotrexate TabletsLindane
go.drugbank.com/drugs/DB00431ApprovedWithdrawnIn Canada, Lindane is not recommmended as a first-line therapy due to reports of resistance, neurotoxicity, and bone marrow suppression, but has been approved by the FDA as a second-line therapy for topical … An organochlorine insecticide that has been used as a pediculicide and a scabicide.
Categories: Compounds used in a research, industrial, or household settingProducts: PMS-lindane Shp 1%, PMS-lindane Lot 1%