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Displaying results 2291 - 2300 of 10000 in total
  1. Drug

    Tebentafusp

    go.drugbank.com/drugs/DB15283
    ApprovedInvestigational

    Tebentafusp is a gp100 peptide-HLA-directed CD3 T cell engager. … [L39995] It is a bispecific, fusion protein and first-in-class drug of immune-mobilizing monoclonal T cell receptors against cancer (ImmTACs), a recently developed cancer immunotherapy with a novel mechanism

    Categories: Bispecific gp100 Peptide-HLA-directed CD3 T Cell Engager
  2. Drug

    Ibudilast

    go.drugbank.com/drugs/DB05266
    Investigational

    Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume … (codes: AV-411 or MN-166), but is approved for use as an antiinflammatory in Japan.

  3. Drug

    Retapamulin

    go.drugbank.com/drugs/DB01256
    Approved

    Retapamulin, marketed by GlaxoSmithKline as the ointment Altabax, is an antibiotic for skin infections like impetigo. It was approved by the FDA in April 2007.

  4. Drug

    Pegvaliase

    go.drugbank.com/drugs/DB12839
    ApprovedInvestigational

    /L to 3690 µmol/L [A33286]. … The primary goal of lifelong treatment of PKU, as recommended by the American College of Medical Genetics and Genomics (ACMG) guidelines, is to maintain blood Phe concentration in the range of 120 µmol

  5. Target

    Proteasome subunit beta type-10

    go.drugbank.com/bio_entities/BE0004738
    TargetHumans

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-depe...

    Polypeptides: Proteasome subunit beta type-10Synonyms: Low molecular mass protein 10
  6. Target

    Keratin, type I cytoskeletal 10

    go.drugbank.com/bio_entities/BE0009062
    TargetHumans

    Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers primarily with the type II keratin KRT1, and also with KRT2, assembling into intermediate filament networks that sup...

    Polypeptides: Keratin, type I cytoskeletal 10Synonyms: CK-10, Keratin-10
  7. Target

    Serine/threonine-protein kinase 10

    go.drugbank.com/bio_entities/BE0009541
    TargetHumans

    Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a neg...

    Polypeptides: Serine/threonine-protein kinase 10
  8. Target

    Interleukin-10 receptor subunit beta

    go.drugbank.com/bio_entities/BE0014312
    TargetHumans

    Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. ...

    Polypeptides: Interleukin-10 receptor subunit betaSynonyms: IL-10R subunit 2, IL-10R subunit beta
  9. Target

    Mitogen-activated protein kinase 10

    go.drugbank.com/bio_entities/BE0001097
    TargetHumans

    Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the...

    Polypeptides: Mitogen-activated protein kinase 10Synonyms: MAPK 10, MAP kinase 10
  10. Target

    Carbonic anhydrase-related protein 10

    go.drugbank.com/bio_entities/BE0003631
    TargetHumans

    Does not have a catalytic activity

    Polypeptides: Carbonic anhydrase-related protein 10