Mitogen-activated protein kinase 10

BE0001097ProteinHumansMAPK10

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. It is acted on by 24 drugs in DrugBank.

Gene name
MAPK10
UniProtKB entry
P53779Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
464 residues · 52,585 Da
Also known as
2.7.11.24 · c-Jun N-terminal kinase 3 · JNK3 · JNK3A · MAP kinase 10

Resolves to

Protein
UniProtP53779UniProt nameMK10_HUMAN
Gene
HGNCHGNC:6872NCBI Gene5602GenBank468151GeneCardsMAPK10
Pharmacology
IUPHAR/GtoPdb1498KEGGhsa:5602
Structure
PDB1JNKPDB1PMNPDB1PMU
Drugs

What you can answer from here — as of September 07, 2019

24DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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71+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase 10, how selective are they, and which programs against it are still in active trials?

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