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Displaying results 2311 - 2320 of 10000 in total
  1. Drug

    MLN0415

    go.drugbank.com/drugs/DB05183
    Experimental

    MLN0415 is a novel, small molecule IKK2 inhibitor, discovered by Millennium scientists. … In preclinical studies, MLN0415 was shown to decrease NF-kB activation and down-regulate the expression of a number of inflammatory proteins.

  2. Drug

    Oxyphencyclimine

    go.drugbank.com/drugs/DB00383
    Approved

    Oxyphencyclimine is an anticholinergic drug (trade name Daricon) used in treating peptic ulcers.

  3. Drug

    Lumacaftor

    go.drugbank.com/drugs/DB09280
    ApprovedInvestigational

    [A20343] Improvements in lung function (ppFEV1) were found to be statistically significant, but minimal, with only a 2.6-3.0% change from baseline with more than 70% of patients failing to achieve an absolute … [A18395] The next most common mutation, G551D, affecting 4-5% of CF patients worldwide, is characterized as a missense mutation, whereby there is sufficient amount of protein at the cell surface, but opening

  4. Drug

    Pegloticase

    go.drugbank.com/drugs/DB09208
    ApprovedInvestigational

    [L42425] Pegloticase was approved by the FDA in 2014, and in 2022, the drug label included the co-administration of pegloticase and methotrexate.[L42425] … Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in adult patients that do not respond to other types of therapies.

  5. Indication

    Follicular Non-Hodgkin's Lymphoma Refractory

    go.drugbank.com/conditions/DBCOND0110844
    Drugs: Bendamustine · Ibritumomab tiuxetan
    Synonyms: Follicular Non-Hodgkin's Lymphoma Refractory, Refractory follicular non-hodgkin lymphoma
  6. Indication

    Inflammatory, non-infectious pruritic dermatosis

    go.drugbank.com/conditions/DBCOND0135056
    Drugs: Heparin
    Synonyms: Inflammatory, non-infectious pruritic dermatosis
  7. Indication

    Non-central Nervous System Pathology

    go.drugbank.com/conditions/DBCOND0158743
    Drugs: Olipudase alfa
    Synonyms: Non-central Nervous System Pathology
  8. Indication

    Primary Non-metastatic Breast Cancer

    go.drugbank.com/conditions/DBCOND0062627
    Drugs: Chymotrypsin
    Synonyms: Primary Non-metastatic Breast Cancer
  9. Indication

    Varicose veins non-site specific

    go.drugbank.com/conditions/DBCOND0027264
    Drugs: beta-Escin
    Synonyms: Varicose veins non-site specific
  10. Drug

    Deuruxolitinib

    go.drugbank.com/drugs/DB18847
    ApprovedInvestigational

    [A264108, A264113, A264123] Deuruxolitinib works to block the inflammatory responses caused by JAKs.[L51068] … [A264113] On July 26, 2024, deuruxolitinib was approved by the FDA for the treatment of severe alopecia areata.