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Letermovir
go.drugbank.com/drugs/DB12070ApprovedInvestigational[A31290] Letermovir has recieved both priority and orphan drug status from the FDA. It is currently marketed under the brand name Prevymis.[L1021] … Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant patients.
Prasugrel
go.drugbank.com/drugs/DB06209ApprovedInvestigationalSimilar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. … Prasugrel was developed by Daiichi Sankyo Co. and is currently marketed in the United States and Canada in cooperation with Eli Lilly and Company for acute coronary syndromes planned for percutaneous coronary
Osilodrostat
go.drugbank.com/drugs/DB11837ApprovedInvestigational[L12123] It has undergone phase II clinical trials for the treatment of solid tumours, hypertension, and heart failure, but development for these indications was discontinued by Novartis in January 2013 … Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol.
Tibolone
go.drugbank.com/drugs/DB09070ApprovedInvestigationalIn June 2006, Organon Pharmaceuticals announced the receipt of a Not Approvable Letter from the U.S. … Tibolone (Livial, Org OD 14), produced by Organon (West Orange, NJ), is a synthetic steroid that possesses estrogenic, androgenic and progestogenic properties.
Hexachlorophene
go.drugbank.com/drugs/DB00756ApprovedWithdrawn(From Martindale, The Extra Pharmacopoeia, 30th ed, p797) … A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms.
International brands: E-Z scrub, Staphene OEflapegrastim
go.drugbank.com/drugs/DB15001ApprovedInvestigational[L43135] Eflapegrastim is a form of recombinant human G-CSF comprising a human G-CSF analog coupled to the Fc fragment of human IgG4 via a polyethylene glycol linker. … [A252320] They trigger signaling pathways that control the differentiation, proliferation, migration, and survival of neutrophils, thereby helping to restore depressed neutrophil counts.
Ethinamate
go.drugbank.com/drugs/DB01031ApprovedIllicitWithdrawnEthinamate is a short-acting sedative-hypnotic medication used to treat insomnia. … Nevertheless, the medication itself is generally no longer effective after using it for greater than 7 days.
Ropeginterferon alfa-2b
go.drugbank.com/drugs/DB15119ApprovedInvestigational[A242000, A242005] [Interferon alfa-2b] has been used for decades to treat PV but requires frequent dosing and is not tolerated by all patients. … [A242005] Ropeginterferon alfa-2b is a next-generation mono-pegylated type I interferon produced from proline-IFN-α-2b in _Escherichia coli_ that has high tolerability and a long half-life.
Fomivirsen
go.drugbank.com/drugs/DB06759ApprovedWithdrawnIt was discovered by scientists at the National Institutes of Health (NIH) and was first developed by _Isis Pharmaceuticals_ and subsequently licensed to _Novartis_ [A31990]. … The drug was withdrawn by the FDA because while there was a high unmet need for drugs to treat CMV when the drug was initially discovered and developed due to the CMV arising in people with AIDS, the development
Botulinum toxin type B
go.drugbank.com/drugs/DB00042ApprovedThe neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation and chromatography steps. … Neurotoxin produced by fermentation of clostridium botulinum type B. The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex.