Search

Displaying results 2341 - 2350 of 2481 in total
  1. Drug

    Remdesivir

    go.drugbank.com/drugs/DB14761
    ApprovedInvestigational

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress s...

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  2. Drug

    Dordaviprone

    go.drugbank.com/drugs/DB14844
    ApprovedInvestigational

    [A274391] Dordaviprone has several modes of action, including the activation of mitochondrial caseinolytic protease P (ClpP), antagonism of the dopamine D2 receptor,[L53833] activation of Activating Transcription

    Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2B6 Inducers
  3. Drug

    Trastuzumab deruxtecan

    go.drugbank.com/drugs/DB14962
    ApprovedInvestigational

    Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. It is classified as an antibody-drug conjugate. The cleavabl...

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  4. Drug

    Acoramidis

    go.drugbank.com/drugs/DB17999
    ApprovedInvestigational

    Acoramidis is a small molecule stabilizer of transthyretin (TTR) for use in patients with TTR amyloidosis. Similar to the previously developed tafamidis, acoramidis is used to stabilize TTR in its tetrameric form, preventing the formatio...

    Categories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
  5. Drug

    Quinoline

    go.drugbank.com/drugs/DB18050
    Investigational

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates
  6. Drug

    Opelconazole

    go.drugbank.com/drugs/DB18251
    Investigational

    Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP3A Inducers
  7. Drug

    CC-90001

    go.drugbank.com/drugs/DB18445
    Investigational

    Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitors
  8. Drug

    Revumenib

    go.drugbank.com/drugs/DB18515
    ApprovedInvestigational

    Abnormal gene rearrangements at chromosome locus 11q23, called KMT2A rearrangements or translocations, are present in 5%-10% of patients with acute leukemias and are the sole genetic aberration found in the majority of infant acute lymph...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors
  9. Drug

    APPD

    go.drugbank.com/drugs/DB18603
    Experimental

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  10. Drug

    P-42 peptide

    go.drugbank.com/drugs/DB18610
    Experimental

    P-42 peptide is a synthetic 23 amino acid peptide AASSGVSTPGSAGHDIITEQPRS derived from the Huntingtin protein