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Pimavanserin
go.drugbank.com/drugs/DB05316ApprovedInvestigationalIn fact, pimavanserin is the first antipsychotic drug without D<sub>2</sub> blocking activity. … [L48236] Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors.
Pexidartinib
go.drugbank.com/drugs/DB12978ApprovedInvestigational[A182243] Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.[L7901] … In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT.
Carbon monoxide
go.drugbank.com/drugs/DB11588ApprovedInvestigationalIt is toxic to hemoglobin utilizing animals (including humans), when encountered in concentrations above about 35 ppm, although it is also formed in normal animal metabolism in low quantities, and is thought … In New Zealand, the use of carbon monoxide in fish preparation has been banned, as it may mask the effects of food spoilage and bacterial growth [L2539].
Synonyms: carbon(II) oxideRoxadustat
go.drugbank.com/drugs/DB04847ApprovedInvestigationalIt works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transcription factor that stimulates red blood cell production in response to low oxygen levels. … Roxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease.
Capivasertib
go.drugbank.com/drugs/DB12218ApprovedInvestigational[A262021] The PIK3/AKT pathway is one of the most commonly activated pathways in breast cancer, mainly through the constitutively active mutation in AKT1, loss of function mutation in PTEN, a negative … PIK3CA/AKT1/PTEN gene(s) in combination with [fulvestrant].
Omidubicel
go.drugbank.com/drugs/DB17132ApprovedInvestigationalIt is administered as a single intravenous dose specific to each patient. … In addition, the fact that 39% of the study's cohort were non-White patients highlights the importance of this type of treatment in key demographics with low donor availability.
Phenyltoloxamine
go.drugbank.com/drugs/DB11160ApprovedIt is available in combination products that also contain other analgesics and antitussives such as acetaminophen. … Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs.
Anthrax vaccine
go.drugbank.com/drugs/DB11003ApprovedInvestigationalIt is subcutaneously or intramuscularly administered. … [L47526] It is considered one of the most likely agents to be used in a biological attack.
Oxilofrine
go.drugbank.com/drugs/DB11610ApprovedOxilofrine is used in combination with [DB11609] as an antitussive. It is currently marketed in Canada by Valeant under the tradename Cophylac.