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Displaying results 2361 - 2370 of 6949 in total
  1. Drug

    Calcitriol

    go.drugbank.com/drugs/DB00136
    ApprovedInvestigationalNutraceutical

    It is also available in topical form for the treatment of mild to moderate plaque psoriasis in adults.

    Categories: Antipsoriatics for Topical Use
  2. Drug

    Pacritinib

    go.drugbank.com/drugs/DB11697
    ApprovedInvestigational

    [L40793] JAK2 signaling is important for hematopoiesis and proper immune functioning,[L40754] and while the precise role it plays in the pathogenesis of MF remains unclear, its clear association with MF … Pacritinib is an inhibitor of both wild-type and mutant (V617F) JAK2, as well as FMS-like tyrosine kinase 3 (FLT3), which was granted accelerated approval by the FDA in February 2022 for the treatment

  3. Drug

    Vismodegib

    go.drugbank.com/drugs/DB08828
    ApprovedInvestigational

    Afterwards, it is silenced in all cells and tissues, except for hair, skin and stem cells. … [A258608,L45803] In January 2012, vismodegib was approved by the FDA for the treatment of adult basal cell carcinoma.

    Categories: Smoothened Receptor Antagonists
  4. Drug

    Ripretinib

    go.drugbank.com/drugs/DB14840
    ApprovedInvestigational

    Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]

    Categories: Stem Cell Factor (KIT) Receptor Inhibitors, Platelet-derived Growth Factor alpha Receptor Inhibitors
  5. Drug

    Nonacog beta pegol

    go.drugbank.com/drugs/DB13933
    ApprovedInvestigational

    It is produced without animal-derived materials and with an attached 40kDa polyethylene glycol (PEG) molecule for peptide activation by a site-directed glycoPEGylation.

  6. Drug

    Alimemazine

    go.drugbank.com/drugs/DB01246
    ApprovedVet approvedWithdrawn

    A phenothiazine derivative that is used as an antipruritic.

    Categories: Antihistamines for Systemic Use
  7. Drug

    Miconazole

    go.drugbank.com/drugs/DB01110
    ApprovedInvestigationalVet approved

    Despite having been in clinical use for an extended period, resistance to miconazole among susceptible organisms is relatively low.[A203636] … [A203636, A203639] Miconazole was first synthesized in 1969 and first granted FDA approval on January 8, 1974, for sale by INSIGHT Pharmaceuticals as a topical cream.

    Categories: Antifungals for Topical Use, Antifungals for Dermatological Use
  8. Drug

    Procaine benzylpenicillin

    go.drugbank.com/drugs/DB09320
    ApprovedVet approved

    Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many infections.

    Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use
  9. Drug

    Sulfacytine

    go.drugbank.com/drugs/DB01298
    Approved

    The inhibited reaction is necessary in these organisms for the synthesis of folic acid. … Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally.

  10. Drug

    Oxethazaine

    go.drugbank.com/drugs/DB12532
    ApprovedWithdrawn

    [A33104] Oxetacaine is approved by Health Canada since 1995 for its use as an antacid combination in over-the-counter preparations.

    Categories: Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use