DB01246ApprovedVet approvedWithdrawnSmall moleculeAntipruriticsHistamine H1 AntagonistsPhenothiazine Derivatives
Alimemazine is an antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria. A phenothiazine derivative that is used as an antipruritic.
- Mechanism
- Curator reviewed
Trimeprazine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.
- Primary indication
- Used to prevent and relieve allergic conditions which cause pruritus (itching) and urticaria (some allergic skin reactions).Curator reviewed · 2 structured indications
- Formula / weight
- C18H22N2S · 298.446 g/mol (avg)
- First approval
- Canada, 2000
- Also known as
- Methylpromazine · Trimeprazine
- Code names
- BAYER-1219 · RP-6549
Resolves to
Clinical / RWD
Structure
InChIKey
ZZHLYYDVIOPZBE-UHFFFAOYSA-NSMILESCC(CN(C)C)CN1C2=CC=CC=C2SC2=CC=CC=C12Targets
What you can answer from here — as of September 23, 2026
1Protein targetEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Alimemazine, and which of those have an active Phase 3 trial?
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