Sulfacytine is a short-acting sulfonamide. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may... Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle.
- Mechanism
- Curator reviewed
Sulfacytine is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
- Primary indication
- Used orally in the treatment of acute urinary tract infections.Curator reviewed
- Formula / weight
- C12H14N4O3S · 294.33 g/mol (avg)
- Also known as
- Sulfacitine
- Code names
- CI-636 · NSC-356717
Resolves to
SIBQAECNSSQUOD-UHFFFAOYSA-NSMILESCCN1C=CC(NS(=O)(=O)C2=CC=C(N)C=C2)=NC1=OWhat you can answer from here — as of September 19, 2026
Which drugs share a target with Sulfacytine, and which of those have an active Phase 3 trial?
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