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Displaying results 2381 - 2390 of 2744 in total
  1. Drug

    Gestonorone

    go.drugbank.com/drugs/DB13230
    Experimental

    Gestonorone is often mistaken for gestonorone capproate which has a different chemical structure.

    Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System
  2. Target

    Serine/threonine-protein kinase mTOR

    go.drugbank.com/bio_entities/BE0002386
    TargetHumans

    Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). … The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity).

    Synonyms: FKBP12-rapamycin complex-associated protein, FK506-binding protein 12-rapamycin complex-associated protein 1
  3. Target

    Proteasome subunit beta type-2

    go.drugbank.com/bio_entities/BE0002349
    TargetHumans

    Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

    Synonyms: Multicatalytic endopeptidase complex subunit C7-I
  4. Drug

    Trimegestone

    go.drugbank.com/drugs/DB13129
    Investigational

    Trimegestone has been used in trials studying the treatment of Postmenopause.

    Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System
  5. Drug

    Epimestrol

    go.drugbank.com/drugs/DB13386
    Experimental

    Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System
  6. Drug

    Silodosin

    go.drugbank.com/drugs/DB06207
    ApprovedInvestigational

    Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α1A subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the...

    Categories: Genito Urinary System and Sex Hormones
  7. Drug

    Zavacorilant

    go.drugbank.com/drugs/DB21509
    Investigational

    The usage of the INN stem '-corilant' in the name indicates that Zavacorilant is a glucocorticoid receptor antagonist (non-steroidal).

  8. Drug

    Neladalkib

    go.drugbank.com/drugs/DB21712
    Investigational

    The usage of the INN stem '-alkib' in the name indicates that Neladalkib is a ALK (anaplastic lymphoma kinase) inhibitor.

  9. Drug

    Xiliertinib

    go.drugbank.com/drugs/DB21453
    Investigational

    The usage of the INN stem '-ertinib' in the name indicates that Xiliertinib is a epidermal growth factor receptor (EGFR) inhibitor.

  10. Drug

    Paltimatrectinib

    go.drugbank.com/drugs/DB21588
    Investigational

    The usage of the INN stem '-trectinib' in the name indicates that Paltimatrectinib is a tropomyosin receptor kinase (TRK) inhibitor.