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Imipenem
go.drugbank.com/drugs/DB01598ApprovedInvestigationalSimilar compounds include [meropenem], known for having greater activity against Gram negative bacteria, and the newer [ertapenem] which exhibits a longer half-life due to increased binding to plasma proteins … Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.
Mixtures: Imipenem and Cilastatin Powder for Injection USP 250 mg/250 mg, Imipenem/Cilastatin Stravencon 250 mg/250 mg Pulver zur Herstellung einer InfusionslösungBirch bark extract
go.drugbank.com/drugs/DB16536ApprovedInvestigational(white birch), although hybrids of both species are used as well. … [L42380] Two oleogel formulations of birch bark extract (Oleogel-S10, 10% of triterpene dry extract in sunflower oil) have been approved by the European Medicines Agency.
Categories: Cytochrome P-450 CYP2C8 Inhibitors, Cytochrome P-450 Enzyme InhibitorsVoxilaprevir
go.drugbank.com/drugs/DB12026ApprovedInvestigationalwith an HCV regimen containing sofosbuvir without an NS5A inhibitor [L935]. … Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV)
Mixtures: VOSEVİ 400 MG/ 100 MG/ 100 MG FİLM KAPLI TABLET, 28 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSilicon
go.drugbank.com/drugs/DB12982ApprovedSilicon is under investigation in clinical trial NCT00103246 (Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II Mycosis Fungoides).
Mixtures: Calcium With Mg Zn Mn Cu CR Si and Vit. C & D, Active Calcium Plus Magnesium, Vitamin D and SiliconPibrentasvir
go.drugbank.com/drugs/DB13878ApprovedInvestigationalPibrentasvir is available as an oral combination therapy with [DB13879] under the brand name Mavyret. … Individual NS5A amino acid substitutions that reduced susceptibility to pibrentasvir include M28G or Q30D in a genotype 1a replicon and P32-deletion in a genotype 1b replicon [L940].
Mixtures: MAVİRET 100 MG/40 MG FİLM KAPLI TABLET, 84 ADET, MAVIRET® 100/40 MG TABLETAS RECUBIERTASCategories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP1A2 InhibitorsAbaloparatide
go.drugbank.com/drugs/DB05084ApprovedInvestigationalAbaloparatide is an N-terminal analog of parathyroid hormone-related protein (PTHrP) [A256778] and an agonist at the parathyroid hormone type 1 (PTH1) receptor. … [A256778] Abaloparatide is an osteoanabolic agent that stimulates bone formation.
Estradiol cypionate
go.drugbank.com/drugs/DB13954ApprovedVet approved[DB00783] is commonly produced with an ester side-chain as endogenous estradiol has very low oral bioavailability on its own (2-10%). … of hypoestrogenism due to hypogonadism [FDA Label].
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesPhenyltoloxamine
go.drugbank.com/drugs/DB11160ApprovedPhenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. … Nevertheless, phenyltoloxamine is used to a fairly limited extent in contemporary medicine, with only very few products involving it as an active ingredient.
Mixtures: Dologesic DF, Flextra-650Tenocyclidine
go.drugbank.com/drugs/DB01520IllicitInvestigationalTenocyclidine (TCP, thienyl cyclohexylpiperidine) is a dissociative anesthetic drug with stimulant and hallucinogenic effects.
Categories: Compounds used in a research, industrial, or household settingUmifenovir
go.drugbank.com/drugs/DB13609Investigational[A191475] Umifenovir is currently being investigated as a potential treatment and prophylactic agent for COVID-19 caused by SARS-CoV2 infections in combination with both currently available and investigational … Its invention is credited to a collaboration between Russian scientists from several research institutes 40-50 years ago, and reports of its chemical synthesis date back to 1993.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates