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Carbazochrome
go.drugbank.com/drugs/DB09012ApprovedWithdrawneither at a local or systemic level [A19744]. … It is not FDA-approved but is available as tablets or IM/SC injections in the treatment of hemorrhages in a number of countries.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsInternational brands: Adcar ACCarboprost tromethamine
go.drugbank.com/drugs/DB00429ApprovedInvestigationalA nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy.
Triazavirin
go.drugbank.com/drugs/DB15622InvestigationalTriazavirin is a guanine nucleotide analog antiviral originally developed in Russia that has shown efficacy against influenza A and B, including the H5N1 strain. … [L12087] Given the similarities between SARS-CoV-2 and H5N1, health officials are investigating Triazavirin as an option to combat SARS-CoV-2, the coronavirus responsible for COVID-19.[A191625]
Astemizole
go.drugbank.com/drugs/DB00637ApprovedWithdrawnAstemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. … It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.
Categories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole, 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazoleRacepinephrine
go.drugbank.com/drugs/DB11124ApprovedIt is an active ingredient in oral inhalation over-the-counter products as racepinephrine hydrochloride. … Racepinephrine is a racemic mixture consisting of d-[DB00668] and l-[DB00668] enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist.
Triflupromazine
go.drugbank.com/drugs/DB00508ApprovedVet approvedA phenothiazine used as an antipsychotic agent and as an antiemetic.
Categories: P-glycoprotein inhibitorsFidaxomicin
go.drugbank.com/drugs/DB08874ApprovedInvestigational[A190501] Because fidaxomicin contains an 18-membered lactone ring in its structure, it is referred to as a macrocyclic lactone antibiotic drug. … [L11575] Fidaxomicin is a naturally-occurring 18-member macrocycle derived from fermentation.
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP3A InhibitorsCabozantinib
go.drugbank.com/drugs/DB08875ApprovedInvestigationalCabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. … [L15123] In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced renal cell carcinoma, and this same formulation gained additional approval in both the US and Canada in 2019
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexTetrachlorodecaoxide
go.drugbank.com/drugs/DB05389ApprovedThe Corporation has commenced a Phase II clinical trial in an effort to demonstrate the efficacy of WF10 in combination with Xeloda (capecitabine) in the treatment of pancreatic cancer. … The Corporation believes the research to-date demonstrates that WF10 acts on macrophages (a type of white blood cell) by modulating the balance between inflammation and phagocytosis, a state in which the
Categories: Compounds used in a research, industrial, or household settingMalic acid
go.drugbank.com/drugs/DB12751InvestigationalMalic acid has been used in trials studying the treatment of Xerostomia, Depression, and Hypertension.
Mixtures: Aminoven Infant 10% w/v, AKE 1100 GLUKOZLU IV SOLOSYONU, 500 ML