Triflupromazine

DB00508ApprovedVet approvedSmall molecule

A phenothiazine used as an antipsychotic agent and as an antiemetic.

Mechanism: Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Triflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT2B).
Curator reviewed
Primary indication: Used mainly in the management of psychoses.Curator reviewed
Formula / weight: C₁₈H₁₉F₃N₂S · 352.417 g/mol (avg)
Also known as: Fluopromazine
Code names: MC 4703 · SKF 4648-A

Resolves to

Compound

UNIIRO16TQF95YCAS146-54-3ChEMBLCHEMBL570ChEBI9711PubChem5568KEGGD00390

Clinical / RWD

RxNorm10805ATCN05AA05PharmGKBPA451773

Structure

InChIKeyXSCGXQMFQXDFCW-UHFFFAOYSA-NSMILESCN(C)CCCN1C2=CC=CC=C2SC2=C1C=C(C=C2)C(F)(F)F

Targets

P14416DRD2P21728DRD1P41595HTR2BP11229CHRM1P08172CHRM2

Transporters

P08183ABCB1

What you can answer from here — as of September 23, 2026

5Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

1,222Drug interactionsStructured to mechanism, not free text

1ATC codeIncluding every combination product, plus 29 drug categories

21+ReferencesStructured and connected to the statements they support

Which drugs share a target with Triflupromazine, and which of those have an active Phase 3 trial?

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