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Dosulepin
go.drugbank.com/drugs/DB09167ApprovedInvestigationalThe use of dosulepsin is only recommended in patients who are intolerant or unresponsive to alternative antidepressant therapies. … Dosulepin (INN, BAN) formerly known as dothiepin (USAN), is a tricyclic antidepressant with anxiolytic properties that is used in several European and South Asian countries, as well as Australia, South
Synonyms: (3E)-3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine, 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepinCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Heterocyclic Compounds, 3-RingAbametapir
go.drugbank.com/drugs/DB11932Approved[L15153] The life cycle of head lice (_Pediculus capitis_) is approximately 30 days, seven to twelve of which are spent as eggs laid on hair shafts near the scalp. … Abametapir is a novel pediculicidal metalloproteinase inhibitor used to treat infestations of head lice.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsIoversol
go.drugbank.com/drugs/DB09134ApprovedInvestigational[L41780] Iodine has a high atomic density, which gives it the ability to attenuate X-rays. … Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues.
Synonyms: N,N'-Bis (2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl) -glycolamido] -2,4,6-triiodoisophthalamideCategories: X-Ray Contrast Activity, X-Ray Contrast Media, IodinatedIvabradine
go.drugbank.com/drugs/DB09083ApprovedInvestigationalIvabradine acts by selectively inhibiting the "funny" channel pacemaker current (If) in the sinoatrial node in a dose-dependent fashion, resulting in a lower heart rate and thus more blood to flow to the … Therefore, as ivabradine is designed as a "pure" heart rate-lowering drug by selectively acting on the If channels, it may offer a more favorable side effect profile due to its lower likelihood of causing
Mixtures: CARIVALAN 25/5, CARIVALAN 6.25/5Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingLerodalcibep
go.drugbank.com/drugs/DB19071ApprovedInvestigational[L54738] Approved by the FDA on December 15, 2025, lerodalcibep is indicated as an adjunct to diet and exercise to reduce low-density lipoprotein cholesterol (LDL-C) in adults with hypercholesterolemia … Lerodalcibep is a recombinant fusion protein that binds to and inhibits proprotein convertase subtilisin kexin type 9 (PCSK9).
Synonyms: Engineered binding protein (1-96) anti-(human proprotein convertase subtilisin/kexin type 9), derived from human tenth fibronectin type iii domain, fused via peptidyl linker (97gsgsgs102) to human serum, Protein lib003 (recombinant human proprotein convertase subtilisin/kexin type 9 ligand-binding tenth fibronectin type iii domain) fusion protein with peptide (synthetic 6-amino acid linker) fusion proteinCategories: Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) InhibitorsFilgotinib
go.drugbank.com/drugs/DB14845ApprovedInvestigationalIn contrast, the newly approved filgotinib is a highly selective JAK1 inhibitor. … [A189165] Filgotinib is currently reserved for patients who cannot tolerate DMARDs, or who have been unable to achieve remission in response to one or more DMARDs.[L16616]
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingPaltusotine
go.drugbank.com/drugs/DB16277ApprovedInvestigationalPaltusotine is a selective somatostatin receptor agonist: It mimics the biological actions of endogenous somatostatin, which activates the somatostatin 2 receptor (SST2) to block the secretion of growth … hormone (GH) and decreases the production of growth-promoting insulin-like growth factor 1 (IGF-1).
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsIptacopan
go.drugbank.com/drugs/DB16200ApprovedInvestigational[A262581] This is of particular importance to PNH, where one of the disease hallmarks is the mutation of the PIGA gene. … Iptacopan is a small-molecule factor B inhibitor previously investigated as a potential treatment for the rare blood disease paroxysmal nocturnal hemoglobinuria (PNH) by inhibiting the complement factor
Synonyms: 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl) benzoic acid, BENZOIC ACID, 4-((2S,4S)-4-ETHOXY-1-((5-METHOXY-7-METHYL-1H-INDOL-4-YL)METHYL)-2-PIPERIDINYL)-Categories: Complement Factor B Inhibitor, Cytochrome P-450 SubstratesSimeprevir
go.drugbank.com/drugs/DB06290ApprovedWithdrawnSimeprevir was approved by the FDA in November 2014 and is marketed under the brand name Olysio as oral tablets. … HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients [L852].
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsIobenguane
go.drugbank.com/drugs/DB06704ApprovedInvestigationalIodine 123 is a cyclotron-produced radionuclide that decays to Te 123 by electron capture. Images are produced by a I123 MIBG scintigraphy. FDA approved on September 19, 2008. … The radioisotope used can either be iodine-123 for imaging or iodine-131 for destruction of tissues that metabolize noradrenaline.
Salts: Iobenguane I 123, Iobenguane I 131Categories: Compounds used in a research, industrial, or household setting