Iobenguane is a radiopharmaceutical agent used for the diagnosis of primary and metastatic pheochromocytoma or neuroblastoma. Synthetic guanethidine derivative that locates phaeochromocytomas and neuroblastomas.
- Mechanism
- Curator reviewed
Structure of iobenguane is similar to noradrenaline so it can be taken up by adrenergic tissue in the adrenal medulla, liver, heart, and spleen. Once taken up by noradrenaline transporters in the adrenergic nerve terminals, it is stored in the presynaptic storage vesicles. The radioactive iodine component is responsible for its imaging properties.
- Primary indication
- Detection of primary and metastatic pheochromocytoma or neuroblastomaCurator reviewed · 9 structured indications
- Formula / weight
- C8H10IN3 · 275.0896 g/mol (avg)
- First approval
- United States, 1994
- Also known as
- 3-iodobenzylguanidine · m-iodobenzylguanidine · Metaiodobenzylguanidine · mIBG
- Brand names
Resolves to
PDWUPXJEEYOOTR-UHFFFAOYSA-NSMILESNC(N)=NCC1=CC(I)=CC=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Iobenguane, and which of those have an active Phase 3 trial?
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