Search
Lindane
go.drugbank.com/drugs/DB00431ApprovedWithdrawnIn Canada, Lindane is not recommmended as a first-line therapy due to reports of resistance, neurotoxicity, and bone marrow suppression, but has been approved by the FDA as a second-line therapy for topical … Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment.
Categories: Compounds used in a research, industrial, or household settingSynonyms: γ-lindane, γ-HexachlorzyklohexanThioproperazine
go.drugbank.com/drugs/DB01622ApprovedIt is used for the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes. … Thioproperazine is a potent neuroleptic with antipsychotic properties.
Categories: Heterocyclic Compounds, 3-Ring, Adrenergic alpha-1 Receptor AntagonistsSynonyms: N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine-2-sulfonamide, N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine-2-sulfonamideDimethicone 410
go.drugbank.com/drugs/DB14005Approved[L2162] The name dimethicone has a lot of nomenclature inconsistencies as it is used to refer to common names, generic names, trade names or even for the listing of mixtures. … [L1769] It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%.
Orciprenaline
go.drugbank.com/drugs/DB00816ApprovedA beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem]
Categories: Agents to Treat Airway Disease, Adrenergic beta-2 Receptor AgonistsAlteplase
go.drugbank.com/drugs/DB00009ApprovedInvestigationalAlteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent.[L43125] It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. … In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplase and fibrin.
Synonyms: t-PA, t-plasminogen activatorProducts: ACTILYSE 20 MG FLAKON, 1 ADET, ACTILYSE 10 MG FLAKON, 1 ADETTisotumab vedotin
go.drugbank.com/drugs/DB16732ApprovedInvestigationalTisotumab vedotin is a tissue factor-directed antibody-drug conjugate (ADC) comprised of an anti-tissue factor (TF) human IgG1-kappa antibody conjugated to monomethyl auristatin E (MMAE), a microtubule-disrupting … Tisotumab vedotin is the first TF-directed ADC [A238914] that works by binding to TFs expressed on solid tumours.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: HuMax-TF-ADCLurasidone
go.drugbank.com/drugs/DB08815ApprovedInvestigationalLurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. … Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesProducts: LURAP® 40, LURAP ® 80Cystine
go.drugbank.com/drugs/DB00138ApprovedInvestigationalNutraceuticalWithdrawnA covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
Synonyms: (R,R)-3,3'-dithiobis(2-aminopropanoic acid), β,β'-dithiodialanineBenzonatate
go.drugbank.com/drugs/DB00868Approved[A5790] Currently, benzonatate is the only non-narcotic antitussive available as a prescription drug. … Benzonatate is an oral antitussive drug used in the relief and suppression of cough in patients older than ten years of age.
Synonyms: 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-butylaminobenzoate, p-butylaminobenzoic acid ω-O-methylnonaethyleneglycol esterProducts: D-TATODosulepin
go.drugbank.com/drugs/DB09167ApprovedInvestigationalThe use of dosulepsin is only recommended in patients who are intolerant or unresponsive to alternative antidepressant therapies. … Dosulepin (INN, BAN) formerly known as dothiepin (USAN), is a tricyclic antidepressant with anxiolytic properties that is used in several European and South Asian countries, as well as Australia, South
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Heterocyclic Compounds, 3-RingSynonyms: (3E)-3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine, 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin