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Displaying results 2461 - 2470 of 8696 in total

Drug
Muparfostat
go.drugbank.com/drugs/DB05808
Investigational
Muparfostat (PI-88) is a mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived from the extracellular phosphomannan of the yeast Pichia (Hansenula) holstii, with potential antiangiogenic
Synonyms: Heparanase inhibitor PI-88
Drug
Ribavirin
go.drugbank.com/drugs/DB00811
ApprovedInvestigational
as an adjunct therapy to various first-line and second-line combination therapies recommended for each genotypes. … Additionally, including ribavirin in the regimen can increase the risk of anemia.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic Use
Drug
Promethazine
go.drugbank.com/drugs/DB01069
ApprovedInvestigational
[A189901] Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting. … Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946.
Categories: Antihistamines for Topical Use, Antihistamines for Systemic Use
Drug
Repaglinide
go.drugbank.com/drugs/DB00912
ApprovedInvestigational
Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). … Meglitnides may have a neutral effect on weight or cause a slight increase in weight.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
Drug
Grazoprevir
go.drugbank.com/drugs/DB11575
Approved
Grazoprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotypes 1 and 4 [synthesis]. … It can be used in patients with compensated cirrhosis, human immunodeficiency virus co-infection, or severe kidney disease.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic Use
Drug
TMC-310911
go.drugbank.com/drugs/DB15623
Investigational
TMC-310911 has shown marked activity against a variety of HIV-1 strains, including multi-PI-resistant strains, and may be less likely to generate resistance, making it a potentially desirable therapy for … both treatment-naive and PI-experienced patients.
Categories: Antivirals for Systemic Use, Experimental Unapproved Treatments for COVID-19
Drug
Cevimeline
go.drugbank.com/drugs/DB00185
Approved
It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome. … Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
Drug
Mirtazapine
go.drugbank.com/drugs/DB00370
ApprovedInvestigational
[T595, L6157] The effects of this drug may be observed as early as 1 week after beginning therapy. … It may improve the symptoms of neurological disorders, reverse weight loss caused by medical conditions, improve sleep, and prevent nausea and vomiting after surgery.[A177811]
Categories: Antidepressive Agents Indicated for Depression, Cytochrome P-450 Substrates
Drug
Boron
go.drugbank.com/drugs/DB11203
ApprovedInvestigational
It is also found for applications including ceramics, high-hardness or abrasive compounds, metal coatings, detergents, bleaching agents, insecticides, semiconductors, magnets, wood preservatives, and an … additive in glass fibers of boron-containing fiberglass for insulation and structural materials.
Mixtures: BIOGROW MIN
Drug
Alfentanil
go.drugbank.com/drugs/DB00802
ApprovedIllicitInvestigational
Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. … It produces an early peak analgesic effect and fast recovery of consciousness.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates