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Temozolomide
go.drugbank.com/drugs/DB00853ApprovedInvestigationalIt is currently marketed under the trademark TEMODAR® by Merck.[L32033] … [A229853, A229888, A229923, L32033] Following initial hydrolysis, further reactions liberate a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein substratesSynonyms: 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide, 8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-oneTrimebutine
go.drugbank.com/drugs/DB09089ApprovedInvestigationalTrimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects. … Trimebutine is not a FDA-approved drug, but it is available in Canada and several other international countries.
Synonyms: 2-Dimethylamino-2-phenylbutyl 3,4,5-trimethoxybenzoatSalts: Trimebutine 3-thiocarbamoylbenzenesulfonateTrabectedin
go.drugbank.com/drugs/DB05109ApprovedInvestigationalTrabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. … Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery.
Categories: Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic IndexProducts: Trabectedin TEVA 1 mg Pulver für ein Konzentrat zur Herstellung einer Infusionslösung, Trabectedin SUN 1 mg Pulver für ein Konzentrat zur Herstellung einer InfusionslösungPancrelipase
go.drugbank.com/drugs/DB00085ApprovedInvestigationalPancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands. … [L2510] For further information on the components of this mixture please visit [DB11065], [DB11066] and [DB13147].
Mixtures: PANKREOFLAT 170/310 MG GRANÜL (22x2 g poşet), İNTESTİNOL 59,4 MG/21,3 MG/71,1 MG KAPLI TABLET, 60 ADETProducts: FESTAL N 220 MG ENTERİK KAPLI TABLET, 50 ADET, FESTAL N 220 MG ENTERİK KAPLI TABLET, 100 ADETTerbutaline
go.drugbank.com/drugs/DB00871ApprovedInvestigational[A230328] It is a selective beta-2 adrenergic agonist used as a bronchodilator in asthmatic patients.[A230333,L32093,L32098] Terbutaline was granted FDA approval on 25 March 1974.[L32088] … Terbutaline was first synthesized in 1966[A230333] and described in the literature in the late 1960s and early 1970s.
Mixtures: BİCANA 1,5 MG/5 ML + 66,5 MG/5 ML ŞURUP, 100 ML, BRELAX 1,5 MG+66,5 MG/5 ML ŞURUP, 100 MLCategories: Adrenergic beta-2 Receptor Agonists, Selective Beta 2-adrenergic AgonistsButylscopolamine
go.drugbank.com/drugs/DB09300ApprovedInvestigationalVet approvedIt is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. … It is not a pain medication in the normal sense, since it does not directly affect pain, but rather works to prevent painful cramps and spasms from occurring.
Mixtures: N-BUTIL BROMURO DE HIOSCINA20MG + DIPIRONA 2500 MG/5 ML, DIPIRONA 2.5 G + HIOSCINA 20 MG/5 ML SOLUCION INYECTABLESynonyms: N-butylscopolammonium, N-butylscopolammonium ionCiprofloxacin
go.drugbank.com/drugs/DB00537ApprovedInvestigational[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] The first ciprofloxacin containing product was FDA approved on 22 October 1987.[L6463] … Ciprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics.
Mixtures: SIPROGUT PLUS %0.3 + %0.1 KULAK DAMLASI, ÇÖZELTİ, 5 ML, InfectoCiproCort 3 mg/ml + 0,25 mg/ml Ohrentropfen, LösungCategories: 4-Quinolones, MATE 1 InhibitorsDabocemagene autoficel
go.drugbank.com/drugs/DB17878InvestigationalDabocemagene autoficel is an _ex vivo_, autologous cell-based gene therapy. It comprises autologous dermal fibroblasts genetically modified to express functional type VII collagen.
Synonyms: (RECOMBINANT LENTIVIRUS VECTOR INXN-2004-TRANSDUCED HUMAN AUTOLOGOUS DYSTROPHIC EPIDERMOLYSIS BULLOSA DERMAL FIBROBLAST CELL FCX-007 INTEGRATED PROVIRAL HUMAN COLLAGEN TYPE VII TRANSGENE COL7A1 PLUS 5', D-FiSaxagliptin
go.drugbank.com/drugs/DB06335ApprovedInvestigationalSaxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
Mixtures: KOMBIGLYZE ® XR 5 MG/ 1000 MG, KOMBIGLYZE XR (TABLETS 5 MG/1000 MG)Categories: Drugs Used in Diabetes, Cytochrome P-450 Substrates5-oxoprolinase
go.drugbank.com/bio_entities/BE0002268TargetEnzymeHumansCatalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate
Polypeptides: 5-oxoprolinaseSynonyms: 5-OPase, 5-oxo-L-prolinase