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Displaying results 2481 - 2490 of 10000 in total

Target
Copper-transporting ATPase 1
go.drugbank.com/bio_entities/BE0003666
TransporterHumans
ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). … In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity)
Polypeptides: Copper-transporting ATPase 1Synonyms: Copper pump 1
Drug
Quinupristin
go.drugbank.com/drugs/DB01369
Approved
The combination of the two components acts synergistically and is more effective in vitro than each component alone. … Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis.
Drug
Lebrikizumab
go.drugbank.com/drugs/DB11914
ApprovedInvestigational
years and older with a body weight of at least 40 kg. … [A262874,A262879] On November 17, 2023, lebrikizumab was approved by the EMA under the brand name EBGLYSS for the treatment of moderate-to-severe atopic dermatitis in adult and adolescent patients 12
Drug
Protein S human
go.drugbank.com/drugs/DB13149
ApprovedInvestigational
It serves as a negative feedback mechanism in the coagulation cascade.
Mixtures: COFACT 500 IU/20 ML IV ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 1 ADET, COFACT 250 IU/10 ML IV ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 1 ADET
Drug
Plicamycin
go.drugbank.com/drugs/DB06810
ApprovedWithdrawn
It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. … Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus.
Categories: Compounds used in a research, industrial, or household setting
Drug
Vezocolmitide
go.drugbank.com/drugs/DB21751
Investigational
Vezocolmitide is under investigation in clinical trial NCT06178679 (Safety and Efficacy of ST-100 (Vezocolmitide) Ophthalmic Solution 60 μg/ml Ophthalmic Solution in Subjects Diagnosed With Dry Eye Disease
Synonyms: ST-100
Drug
Aliskiren
go.drugbank.com/drugs/DB09026
ApprovedInvestigational
[A203624] It was developed by Speedel and Novartis and initially approved by the FDA in early 2007. … [L14018] Aliskiren has been proven to efficacious in reducing blood pressure when used alone or in conjunction with other antihypertensive agents.[A203624]
Categories: Agents Acting on the Renin-Angiotensin System
Drug
Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB10793
ApprovedInvestigational
Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals. … In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques.
Mixtures: INFLUVAC TETRA, SUSPENSION FOR INJECTION IN PRE-FILLED SYRINGE 0.5 ML, Fluarix Quadrivalent 2019/2020
Drug
Inositol nicotinate
go.drugbank.com/drugs/DB08949
ApprovedWithdrawn
It is used in food supplements as a source of niacin (vitamin B3), where hydrolysis of 1 g (1.23 mmol) inositol hexanicotinate yields 0.91 g nicotinic acid and 0.22 g inositol. … Nicotinic acid plays an essential role in many important metabolic processes and has been used as lipid-lowering agent.
Mixtures: Inositol Nicotinate 250 mg, Inositol Nicotinate 250 mgCategories: Vitamin B Complex
Drug
Bromothalonil
go.drugbank.com/drugs/DB14199
Approved
In 2005, MDBGN was named in the top 15 most frequently positive allergens identified in patch tests by the North American Contact Dermatitis Group (NACDG)[A34326]. … It is also a known allergen and dermatological irritant that has been banned in many EU countries due to increasing rates of contact allergy [A34322].
Categories: Compounds used in a research, industrial, or household setting