Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated)

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Fluarix Quadrivalent 2021-2022, Fluzone High-Dose Quadrivalent Northern Hemisphere, Fluzone Quadrivalent, Fluzone Quadrivalent Southern Hemisphere
Generic Name
Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated)
DrugBank Accession Number
DB10793
Background

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen". This defence includes the production of humoral immunity through the development of antibodies (through memory B cells) and of cell-mediated immunity through the production of T-lymphocytes. Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy the virus as there are circulating antibodies that recognize that particular component of the virus that it was previously exposed to.

There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV). Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals. In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques. Live vaccines maintain their replicative ability.

Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Vaccines
Inactivated
Synonyms
Not Available

Pharmacology

Indication

Not Available

Pharmacology
Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events & improve clinical decision support.
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
Learn more
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Products2
Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Active Moieties
NameKindUNIICASInChI Key
Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (formaldehyde inactivated)hemagglutinin9HB0XUS9TMNot AvailableNot applicable
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Fluarix 2015/2016Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Christchurch/16/2010 NIB-74XP (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Switzerland/9715293/2013 NIB-88 (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL)SuspensionIntramuscularGlaxoSmithKline Biologicals SA2015-08-032015-08-04US flag
Fluarix Quadrivalent 2015/2016Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Christchurch/16/2010 NIB-74XP (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Switzerland/9715293/2013 NIB-88 (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) (15 ug/0.5mL)SuspensionIntramuscularGlaxoSmithKline Biologicals SA2015-07-012015-06-30US flag
Fluarix Quadrivalent 2016/2017Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Christchurch/16/2010 NIB-74XP (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Hong Kong/4801/2014 X-263B (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) (15 ug/0.5mL)SuspensionIntramuscularGlaxoSmithKline Biologicals SA2016-07-012016-05-31US flag
Fluarix Quadrivalent 2017/2018Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Hong Kong/4801/2014 X-263B (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Singapore/gp1908/2015 IVR-180 (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) (15 ug/0.5mL)SuspensionIntramuscularGlaxoSmithKline Biologicals SA2017-07-072018-06-30US flag
Fluarix Quadrivalent 2018/2019Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Singapore/INFIMH-16-0019/2016 NIB-104 (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Singapore/gp1908/2015 IVR-180 (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Maryland/15/2016 BX-69A antigen (formaldehyde inactivated) (15 ug/0.5mL)SuspensionIntramuscularGlaxoSmithKline Biologicals SA2018-06-292019-06-30US flag
Fluarix Quadrivalent 2019/2020Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Brisbane/02/2018 IVR-190 (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Kansas/14/2017 X-327 (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Maryland/15/2016 BX-69A antigen (formaldehyde inactivated) (15 ug/0.5mL)SuspensionIntramuscularGlaxoSmithKline Biologicals SA2019-07-022020-06-30US flag
Fluarix Quadrivalent 2020/2021Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Guangdong-Maonan/SWL1536/2019 CNIC-1909 (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Hong Kong/2671/2019 NIB-121 (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Washington/02/2019 antigen (formaldehyde inactivated) (15 ug/0.5mL)SuspensionIntramuscularGlaxoSmithKline Biologicals SA2020-07-022021-06-30US flag
Fluarix Quadrivalent 2021/2022Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Tasmania/503/2020 IVR-221 (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Victoria/2570/2019 IVR-215 (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Washington/02/2019 antigen (formaldehyde inactivated) (15 ug/0.5mL)SuspensionIntramuscularGlaxoSmithKline Biologicals SA2021-07-022022-06-30US flag
FLUARIX TETRAInfluenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 mcg/0.5ml) + Influenza A virus A/Guangdong-Maonan/SWL1536/2019 CNIC-1909 (H1N1) antigen (formaldehyde inactivated) (15 mcg/0.5ml) + Influenza A virus A/Hong Kong/2671/2019 IVR-208 (H3N2) antigen (formaldehyde inactivated) (15 mcg/0.5ml) + Influenza B virus B/Washington/02/2019 antigen (formaldehyde inactivated) (15 mcg/0.5ml)Injectionบริษัท แกล็กโซสมิทไคล์น (ประเทศไทย) จำกัด2016-10-10Not applicableThailand flag
Fluarix Tetra Influenza VaccineInfluenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Guangdong-Maonan/SWL1536/2019 CNIC-1909 (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Hong Kong/2671/2019 NIB-121 (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Washington/02/2019 antigen (formaldehyde inactivated) (15 ug/0.5mL)Injection, suspensionIntramuscularGLAXOSMITHKLINE PHARMACEUTICAL SDN. BHD.2020-09-08Not applicableMalaysia flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
B93BQX9789
CAS number
Not Available

References

General References
Not Available
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionFlu caused by Influenza1
4CompletedPreventionFlu caused by Influenza / Influenza, Vaccination / Vaccinations1
4CompletedPreventionInfluenza Vaccine, Influenza1
4CompletedTreatmentCerebrovascular Accident / Heart Failure / Influenza Vaccine, Influenza / Influenza, Human / Myocardial Infarction1
3RecruitingPreventionFlu caused by Influenza1
2CompletedBasic ScienceAcquired Immunodeficiency Syndrome (AIDS) Virus1
Not AvailableCompletedNot AvailableFlu caused by Influenza1
Not AvailableEnrolling by InvitationNot AvailableArsenic--Toxicology / Flu caused by Influenza / Immunologic Disorders Complicating Pregnancy / Micronutrient Deficiency / Vaccine Response Impaired1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SuspensionIntramuscular
Injection
SprayNasal
Injection, suspensionIntramuscular
KitTopical
Injection, solutionIntramuscular
Injection, suspension
Injection, suspensionIntramuscular; Subcutaneous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on December 01, 2015 20:04 / Updated on July 22, 2021 04:38