This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Brand Names
- Fluarix Quadrivalent, Fluzone High-Dose Quadrivalent, Fluzone Quadrivalent
- Generic Name
- Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated)
- DrugBank Accession Number
- DB10793
- Background
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen". This defence includes the production of humoral immunity through the development of antibodies (through memory B cells) and of cell-mediated immunity through the production of T-lymphocytes. Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy the virus as there are circulating antibodies that recognize that particular component of the virus that it was previously exposed to.
There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV). Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals. In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques. Live vaccines maintain their replicative ability.
- Type
- Biotech
- Groups
- Approved, Investigational
- Biologic Classification
- Vaccines
Inactivated - Synonyms
- Not Available
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Active Moieties
Name Kind UNII CAS InChI Key Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (formaldehyde inactivated) hemagglutinin 9HB0XUS9TM Not Available Not applicable - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Fluad Tetra Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 μg) + Citric acid (0.04 mg) + Influenza A virus A/Cambodia/e0826360/2020 IVR-224 (H3N2) antigen (formaldehyde inactivated) (15 μg) + Influenza A virus A/Victoria/2570/2019 IVR-215 (H1N1) antigen (formaldehyde inactivated) (15 μg) + Influenza virus type B (Victoria) (15 μg) + Polysorbate 80 (1.175 mg) + Sodium citrate (0.66 mg) + Sorbitol (1.175 mg) + Squalene (9.75 mg) Injection, suspension Intramuscular Seqirus Netherlands B.V. 2022-06-06 Not applicable EU 
Fluad Tetra Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 μg) + Citric acid (0.04 mg) + Influenza A virus A/Cambodia/e0826360/2020 IVR-224 (H3N2) antigen (formaldehyde inactivated) (15 μg) + Influenza A virus A/Victoria/2570/2019 IVR-215 (H1N1) antigen (formaldehyde inactivated) (15 μg) + Influenza virus type B (Victoria) (15 μg) + Polysorbate 80 (1.175 mg) + Sodium citrate (0.66 mg) + Sorbitol (1.175 mg) + Squalene (9.75 mg) Injection, suspension Intramuscular Seqirus Netherlands B.V. 2022-06-06 Not applicable EU Fluad Tetra Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 μg) + Citric acid (0.04 mg) + Influenza A virus A/Cambodia/e0826360/2020 IVR-224 (H3N2) antigen (formaldehyde inactivated) (15 μg) + Influenza A virus A/Victoria/2570/2019 IVR-215 (H1N1) antigen (formaldehyde inactivated) (15 μg) + Influenza virus type B (Victoria) (15 μg) + Polysorbate 80 (1.175 mg) + Sodium citrate (0.66 mg) + Sorbitol (1.175 mg) + Squalene (9.75 mg) Injection, suspension Intramuscular Seqirus Netherlands B.V. 2022-06-06 Not applicable EU Fluad Tetra Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 μg) + Citric acid (0.04 mg) + Influenza A virus A/Cambodia/e0826360/2020 IVR-224 (H3N2) antigen (formaldehyde inactivated) (15 μg) + Influenza A virus A/Victoria/2570/2019 IVR-215 (H1N1) antigen (formaldehyde inactivated) (15 μg) + Influenza virus type B (Victoria) (15 μg) + Polysorbate 80 (1.175 mg) + Sodium citrate (0.66 mg) + Sorbitol (1.175 mg) + Squalene (9.75 mg) Injection, suspension Intramuscular Seqirus Netherlands B.V. 2022-06-06 Not applicable EU Fluarix 2015/2016 Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Christchurch/16/2010 NIB-74XP (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Switzerland/9715293/2013 NIB-88 (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) Suspension Intramuscular GlaxoSmithKline Biologicals SA 2015-08-03 2015-08-04 US 
Fluarix Quadrivalent 2015/2016 Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Christchurch/16/2010 NIB-74XP (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Switzerland/9715293/2013 NIB-88 (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) (15 ug/0.5mL) Suspension Intramuscular GlaxoSmithKline Biologicals SA 2015-07-01 2015-06-30 US Fluarix Quadrivalent 2016/2017 Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Christchurch/16/2010 NIB-74XP (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Hong Kong/4801/2014 X-263B (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) (15 ug/0.5mL) Suspension Intramuscular GlaxoSmithKline Biologicals SA 2016-07-01 2016-05-31 US Fluarix Quadrivalent 2017/2018 Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Hong Kong/4801/2014 X-263B (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Singapore/gp1908/2015 IVR-180 (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) (15 ug/0.5mL) Suspension Intramuscular GlaxoSmithKline Biologicals SA 2017-07-07 2018-06-30 US Fluarix Quadrivalent 2018/2019 Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Singapore/INFIMH-16-0019/2016 NIB-104 (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Singapore/gp1908/2015 IVR-180 (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Maryland/15/2016 BX-69A antigen (formaldehyde inactivated) (15 ug/0.5mL) Suspension Intramuscular GlaxoSmithKline Biologicals SA 2018-06-29 2019-06-30 US Fluarix Quadrivalent 2019/2020 Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Brisbane/02/2018 IVR-190 (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Kansas/14/2017 X-327 (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Maryland/15/2016 BX-69A antigen (formaldehyde inactivated) (15 ug/0.5mL) Suspension Intramuscular GlaxoSmithKline Biologicals SA 2019-07-02 2020-06-30 US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- B93BQX9789
- CAS number
- Not Available
References
- General References
- Not Available
- External Links
- Not Available
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Flu caused by Influenza 1 4 Completed Prevention Flu caused by Influenza / Influenza, Vaccination / Vaccinations 1 4 Completed Prevention Influenza Vaccine, Influenza 1 4 Completed Treatment Cerebrovascular Accident / Heart Failure / Influenza Vaccine, Influenza / Influenza, Human / Myocardial Infarction 1 4 Recruiting Treatment Type 1 Diabetes Mellitus 1 3 Recruiting Prevention Flu caused by Influenza 1 2 Completed Basic Science Acquired Immunodeficiency Syndrome (AIDS) Virus 1 Not Available Active Not Recruiting Not Available Seasonal Influenza Vaccination 1 Not Available Completed Not Available Arsenic--Toxicology / Flu caused by Influenza / Immunologic Disorders Complicating Pregnancy / Micronutrient Deficiency / Vaccine Response Impaired 1 Not Available Completed Not Available Flu caused by Influenza 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Suspension Intramuscular Injection Spray Nasal Injection, suspension Intramuscular Kit Topical Injection Intramuscular Injection, solution Intramuscular Injection, suspension Injection, suspension Intramuscular; Subcutaneous - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at December 01, 2015 20:04 / Updated at July 22, 2021 04:38