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Agomelatine
go.drugbank.com/drugs/DB06594ApprovedInvestigationalThe Committee for Medical Products for Human Use (CHMP) recommended refusal of marketing authorization on 27 July 2006. The major concern was that efficacy had not been sufficiently shown. … Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: VALDOXAN® 25 MG, ALODIL®25 MGTABLETARECUBIERTAMirtazapine
go.drugbank.com/drugs/DB00370ApprovedInvestigationalIt may improve the symptoms of neurological disorders, reverse weight loss caused by medical conditions, improve sleep, and prevent nausea and vomiting after surgery.[A177811] … [T595, L6157] The effects of this drug may be observed as early as 1 week after beginning therapy.
Categories: Cytochrome P-450 Substrates, Adrenergic alpha-2 Receptor AntagonistsSynonyms: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine, 6-AzamianserinUridine triacetate
go.drugbank.com/drugs/DB09144ApprovedBy pre-administering with uridine (as the prodrug uridine triacetate), higher doses of 5-FU can be given allowing for improved efficacy and a reduction in toxic side effects [A18578]. … It reduces toxicity and cell-death associated with two cytotoxic intermediates: 5-fluoro-2'-deoxyuridine-5'-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP).
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2',3',5'-tri-O-acetyluridine, 2',3',5'-TriacetyluridineButabarbital
go.drugbank.com/drugs/DB00237ApprovedIllicitWithdrawn[A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative anxiety. … [A19735] Its short duration of action gives butabarbital a high abuse potential, comparable to [secobarbital].[A201977,A201980] Butabarbital was granted FDA approval on 5 June 1939.[L13613]
Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-ethyl-5-(1-methylpropyl)barbituric acid, 5-ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrioneNusinersen
go.drugbank.com/drugs/DB13161ApprovedInvestigationalAn antisense oligonucleotide that induces survival motor neuron (SMN) protein expression, it was approved by the U.S. FDA in December, 2016 as Spinraza for the treatment of children and adults with spinal muscular atrophy (SMA). It is ad...
Categories: Survival Motor Neuron-2-directed RNA InteractionProducts: SPİNRAZA 12 MG/5 ML INTRATEKAL ENJEKSİYONLUK ÇÖZELTİ, 1 ADET, SPINRAZA ®12 MG SOLUCION INYECTABLEAzadirachtin
go.drugbank.com/drugs/DB19419InvestigationalAzadirachtin is under investigation in clinical trial NCT06617026 (Short-term Outcome of Medical vs. Surgical Management of Chronic Anal Fissure).
Categories: Compounds used in a research, industrial, or household settingSynonyms: Azadirachtin aFlurbiprofen
go.drugbank.com/drugs/DB00712ApprovedInvestigationalFlurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.
Mixtures: MAJEZIK DUO %5 + %0.25 TOPIKAL JEL, 50 G, MERDEX DUO %5 + %0.25 TOPIKAL JEL, 30 GCategories: Cytochrome P-450 Substrates, Non COX-2 selective NSAIDSMethimazole
go.drugbank.com/drugs/DB00763ApprovedInvestigationalMethimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones. … [L8336,L8339] On a weight basis, methimazole is 10 times more potent than the other major antithyroid thionamide used in North America, [propylthiouracil],[L8339] and is the active metabolite of the
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2A6 InhibitorsSynonyms: 1-Methylimidazole-2(3H)-thionePotassium bitartrate
go.drugbank.com/drugs/DB11107ApprovedInvestigationalPotassium bitartrate has a long history of medical use as a laxative administered as a rectal suppository and is an approved third-class OTC drug in Japan. … It is obtained as a byproduct of wine manufacture during the fermentation process.