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Aripiprazole lauroxil
go.drugbank.com/drugs/DB14185ApprovedThe patients may receive Aristada Initio in combination with a single 30 mg oral dose of aripiprazole to achieve appropriate levels of aripiprazole more rapidly. … It is a prodrug of [aripiprazole], which acts as a partial agonist at the D2 and 5-HT1A receptors, and as an antagonist at the 5-HT2A receptors [A34289].
Categories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2A Receptor AntagonistsNifurtimox
go.drugbank.com/drugs/DB11820ApprovedInvestigationalIt is commonly known as American Trypanosomiasis. … Chagas disease, caused by a parasite known as Trypanosoma cruzi (T.cruzi), is a vector-transmitted disease affecting animals and humans in the Americas.
Tebentafusp
go.drugbank.com/drugs/DB15283ApprovedInvestigationalEven after surgical ablation or removal of the ocular tumour, almost 50% of patients with uveal melanoma develop metastatic disease. … [L39995] Tebentafusp was subsequently approved for the same indication in the EU in April 2022.[L41675]
Iopodic acid
go.drugbank.com/drugs/DB09333ApprovedWithdrawnOn September 22, 1981, ipodate was submitted again by the company Schering AG but it is currently under an inactive status.[L1082] … It was developed and filed to the FDA by the company BRACCO. This drug was approved on March 15, 1962 but it is nowadays discontinued from the FDA and Health Canada.
Amcipatricin
go.drugbank.com/drugs/DB12333InvestigationalSPK-843 doses of higher than 1.0 mg/kg of body weight exhibit no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone … Amcipatricin has been used in trials studying the treatment of Cryptococcosis or Aspergillosis Infections.
Ethynodiol diacetate
go.drugbank.com/drugs/DB00823Approvedthat has never been marketed, see [DB13866]). … A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
Synonyms: 3β,17β-Diacetoxy-19-nor-17α-pregn-4-en-20-yne, 19-Nor-17α-pregn-4-en-20-yne-3β,17-diol diacetateMixtures: Kelnor 1/50, Valtya 1/50Panobinostat
go.drugbank.com/drugs/DB06603ApprovedInvestigationalPanobinostat acts as a non-selective histone deacetylase inhibitor (pan-HDAC inhibitor) and it is the most potent DAC inhibiting agent available on the market. … The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress of being conducted
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsMD-0727
go.drugbank.com/drugs/DB05948InvestigationalMD-0727 is a novel, potent cholesterol absorption inhibitor (CAI) under investigation for the treatment of hypercholesterolemia (high cholesterol.
Medrogestone
go.drugbank.com/drugs/DB09124ApprovedWithdrawn[L1118] It was never approved by the FDA. … It was conceived as an alternative for an orally effective contraceptive option.[A31526] It was developed by Ayerst, approved in Canada in 1969 and its current status is cancelled post-marketing.
Mixtures: PRESOMEN 28 COMP 0.3/5MG, PRESOMEN 28 COMP 0.3/5MGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesMC-1
go.drugbank.com/drugs/DB05315ExperimentalMedicure's MC-1 drug is a cardio-protectant, designed to reduce the damage to the heart when arteries are blocked and when they are subsequently reopened after bypass surgery.
Synonyms: MC-1