Search
Cabergoline
go.drugbank.com/drugs/DB00248ApprovedInvestigationalCabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: 1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'β-carbonyl)urea, (8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamidePhenytoin
go.drugbank.com/drugs/DB00252ApprovedInvestigationalVet approvedPhenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.
Mixtures: Dilantin W Phenobarbital 15mg, Dilantin W Phenobarbital 30mg CapCategories: Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexDiethylstilbestrol
go.drugbank.com/drugs/DB00255ApprovedWithdrawnA synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. … According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: (E)-3,4-bis(4-hydroxyphenyl)-3-hexene, α,α'-diethyl-(E)-4,4'-stilbenediolClotrimazole
go.drugbank.com/drugs/DB00257ApprovedInvestigationalVet approvedThis drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. … As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094].
Mixtures: LINDAZOL-2 ®, LINDAZOL-2 ®Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsCycloserine
go.drugbank.com/drugs/DB00260ApprovedInvestigationalAntibiotic substance produced by Streptomyces garyphalus.
Synonyms: D-4-amino-3-isoxazolidone, D-4-amino-3-isoxazolidinoneCategories: Heterocyclic Compounds, 1-RingDicoumarol
go.drugbank.com/drugs/DB00266ApprovedDicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K.
Categories: 4-Hydroxycoumarins, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic IndexSynonyms: 3,3'-methylenebis(4-hydroxy-2H-1-benzopyran-2-one), bis(4-hydroxycoumarin-3-yl)methaneIsradipine
go.drugbank.com/drugs/DB00270ApprovedIt exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: OPTASIL ®, CALBLOCK® TABLETASBetazole
go.drugbank.com/drugs/DB00272ApprovedA histamine H2 agonist used clinically to test gastric secretory function.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2-(3-pyrazolyl)ethylamine, 3-(2-aminoethyl)pyrazoleCefmetazole
go.drugbank.com/drugs/DB00274ApprovedA semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. … It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.
Categories: Heterocyclic Compounds, 2-RingSynonyms: (6R,7S)-7-({[(cyanomethyl)sulfanyl]acetyl}amino)-7-methoxy-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidAmsacrine
go.drugbank.com/drugs/DB00276ApprovedInvestigationalWithdrawnAminoacridine derivative that is a potent intercalating antineoplastic agent.
Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 3-RingSynonyms: 4'-(9-Acridinylamino)-3'-methoxymethanesulfonanilide, 4'-(9-Acridinylamino)methanesulfon-m-anisidide