Cycloserine is a broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI). Antibiotic substance produced by Streptomyces garyphalus.
- Mechanism
- Curator reviewed
Cycloserine is an analog of the amino acid D-alanine. It interferes with an early step in bacterial cell wall synthesis in the cytoplasm by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis.
- Primary indication
- Used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).Curator reviewed · 3 structured indications
- Formula / weight
- C3H6N2O2 · 102.0919 g/mol (avg)
- First approval
- Canada, 1994 · United States, 1956
- Also known as
- alpha-Cycloserine · cyclo-D-Serine · D-Cycloserine · Orientomycin
- Code names
- NSC-154851 · NSC-76029 · PA-94 · Ro-1-9213
- Brand names
Resolves to
DYDCUQKUCUHJBH-UWTATZPHSA-NSMILESN[C@@H]1CONC1=OWhat you can answer from here — as of September 12, 2026
Which drugs share a target with Cycloserine, and which of those have an active Phase 3 trial?
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