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Keratin, type I cytoskeletal 10
go.drugbank.com/bio_entities/BE0009062TargetHumansStructural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers primarily with the type II keratin KRT1, and also with KRT2, assembling into intermediate filament networks that sup...
Polypeptides: Keratin, type I cytoskeletal 10Keratin, type I cytoskeletal 9
go.drugbank.com/bio_entities/BE0009064TargetHumansStructural component of intermediate filaments in suprabasal keratinocytes of palmoplantar epidermis. Forms heteropolymers with a type II keratin, assembling into keratin intermediate filament networks that maintain the mechanical integr...
Polypeptides: Keratin, type I cytoskeletal 914-3-3 protein I
go.drugbank.com/bio_entities/BE0009206TargetPlasmodium falciparum (isolate 3D7)Adapter protein which binds to its partners, usually via a phosphoserine or phosphothreonine motif (PubMed:23308157, PubMed:32484216, PubMed:32817103). Binding generally results in the modulation of the activity and/or cellular localizat...
Polypeptides: 14-3-3 protein ICasein kinase I isoform alpha
go.drugbank.com/bio_entities/BE0009427TargetHumansCasein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Phosphorylates a large number of proteins (P...
Polypeptides: Casein kinase I isoform alphaHydromorphone
go.drugbank.com/drugs/DB00327ApprovedIllicitInvestigational[A176495] The first reported approved product containing hydromorphone in the form of hydromorphone hydrochloride was developed by Fresenius Kabi USA and FDA approved in 1984.[L5795] … Due to these modifications, it presents a very high potency and comparable side effect profile to the parent compound.
Synonyms: 6-Deoxy-7,8-dihydro-6-oxomorphine, 4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-oneCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesPotassium nitrate
go.drugbank.com/drugs/DB11090ApprovedInvestigationalIn addition, potassium nitrate is used as a diuretic in pigs, cattle, and horses. It is administered orally doses up to 30 g per animal per day [L1736]. … Potassium nitrate is an inorganic salt with a chemical formula of KNO3.
Mixtures: DOLNI - K GEL CON FLUOR, DOLNI-K GEL CON FLUORUROCategories: Compounds used in a research, industrial, or household settingOspemifene
go.drugbank.com/drugs/DB04938ApprovedOspemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause … FDA approved on February 26, 2013.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesSynonyms: 2-(4-(4-Chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol, 2-(p-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanolNo Neurological Problems
go.drugbank.com/conditions/DBCOND0073979Drugs: ImigluceraseSynonyms: No Neurological ProblemsEthchlorvynol
go.drugbank.com/drugs/DB00189ApprovedIllicitWithdrawnEthchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists.
Synonyms: 1-chloro-3-ethyl-1-penten-4-yn-3-ol, 1-Chloro-3-ethyl-pent-1-en-4-yn-3-olProducts: Placidyl Cap 750mg, Placidyl Cap 200mgIbuprofen
go.drugbank.com/drugs/DB01050ApprovedInvestigationalOnce administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase. … [A39075] Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.
Synonyms: (±)-α-methyl-4-(2-methylpropyl)benzeneacetic acid, (±)-2-(p-isobutylphenyl)propionic acidInternational brands: Cap-Profen, Act-3