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Bortezomib
go.drugbank.com/drugs/DB00188ApprovedInvestigational[A204083] In May 2003, bortezomib became the first anticancer proteasome inhibitor that was approved by the FDA under the trade name VELCADE. … [L14180] However, multiple mechanisms may be involved in the anticancer activity of bortezomib.[A204083] Bortezomib was first synthesized in 1995.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: Abormib 1 mg-Pulver zur Herstellung einer Injektionslösung, Abormib 2,5 mg-Pulver zur Herstellung einer InjektionslösungBevacizumab
go.drugbank.com/drugs/DB00112ApprovedInvestigationalvials formulated for intravenous oncology use. … [A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its attractiveness as a therapeutic target.
Categories: Experimental Unapproved Treatments for COVID-19, VEGF/VEGFR (Vascular Endothelial Growth Factor / -Receptor) inhibitorsProducts: ZIRABEV CONCENTRATE FOR SOLUTION FOR INFUSION 100 MG/4 ML, ZIRABEV CONCENTRATE FOR SOLUTION FOR INFUSION 400 MG/16 MLClonidine
go.drugbank.com/drugs/DB00575ApprovedInvestigationalClonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.
Categories: Antihypertensive Agents Indicated for Hypertension, Cytochrome P-450 SubstratesProducts: Mar-clonidineAlbuterol
go.drugbank.com/drugs/DB01001ApprovedInvestigationalVet approvedThe R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. … It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart.
Mixtures: COMBIVENT UNIT DOSE VIAL FOR INHALATION, Combivent Lösung für einen Vernebler in EinzeldosisbehältnissenCategories: Drugs for Obstructive Airway Diseases, Cytochrome P-450 CYP3A InhibitorsTPIV 200
go.drugbank.com/drugs/DB17318InvestigationalTPIV 200 is a vaccine consisting of proteins from the folate receptor alpha mixed with Granulocyte-macrophage colony-stimulating factor (GM-CSF).
Synonyms: TPIV200/huFR-1Semzuvolimab
go.drugbank.com/drugs/DB18920InvestigationalSemzuvolimab is under investigation in clinical trial NCT03149211 (To Investigate the Efficacy and Safety of UB-421 Monotherapy in HIV-1 Infected Adults).
Synonyms: DB4C7 mAb, Mab db4c7ChAd-triCoV/Mac
go.drugbank.com/drugs/DB24997InvestigationalChAd-triCoV/Mac is a biologic drug. ChAd-triCoV/Mac is under investigation in clinical trial NCT06381739 (A Trial of a Next Generation COVID-19 Vaccine Delivered by Inhaled Aerosol).
Synonyms: ChAd-triCoV/MacPertuzumab
go.drugbank.com/drugs/DB06366ApprovedInvestigationalIt was first approved by the FDA in 2012 for use with [docetaxel] and another HER2-targeted monoclonal antibody, [trastuzumab], in the treatment of metastatic HER2-positive breast cancer. … Its indicated conditions have since expanded to include use as both a neoadjuvant therapy and an adjuvant therapy in the treatment of HER2-positive breast cancers at high risk of recurrence.
Categories: HER2 Receptor Antagonists, Receptor, ErbB-2, antagonists & inhibitorsProducts: Perjeta 420 mg concentrate for solution for infusion, PERJETA CONCENTRATE FOR SOLUTION FOR INFUSION 420MG/14MLOndansetron
go.drugbank.com/drugs/DB00904ApprovedInvestigationalWithdrawn[L5221] The FDA withdrew its approval for the use of all intravenous drug products containing more than 16 mg of ondansetron hydrochloride in a single dose, due to a high risk of QT prolongation. … A competitive serotonin type 3 receptor antagonist.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: Mar-ondansetron, Mar-ondansetron ODTVitamin A
go.drugbank.com/drugs/DB00162ApprovedInvestigationalNutraceuticalVet approvedRetinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the
Mixtures: Mag-A-folic Tab, Doctor's Choice Brand for MenCategories: Tests for Fat Absorption, Anti-Acne Preparations for Topical Use