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Elinzanetant
go.drugbank.com/drugs/DB18968ApprovedInvestigationalElinzanetant is a non-hormonal, selective, dual neurokinin 1 (NK-1) and 3 (NK-3) receptor antagonist. … [L53798] Later the same year, it was approved in the US for the same indication. [L54216]
Linezolid
go.drugbank.com/drugs/DB00601ApprovedInvestigationalLinezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. … [A233425] A second member of this class, [tedizolid], was approved by the FDA in 2014 and is considered generally more effective and tolerable than its predecessor.
Products: DILOZELD-UF 2MG/ML SOLUCIÓN PARA INFUSIÓNFilgrastim
go.drugbank.com/drugs/DB00099ApprovedInvestigational[L40714] Filgrastim was approved in the US in 1991 and there are biosimilars available with similar therapeutic indications.[A245858] Tbo-filgrastim was approved by the FDA on August 29, 2012. … It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the sequence for expression in _E. Coli_.
Products: NEUPOGEN 30 MIO U 0.3MG/ML VIAL, INMUNEF 30 UI SOLUCION INYECTABLEInsulin icodec
go.drugbank.com/drugs/DB16693ApprovedInvestigational[L50758,A263818] Insulin icodec was approved by Health Canada in March 2024 for the treatment of adult patients with type 1 or 2 diabetes mellitus,[L50758] and was subsequently approved by the EMA in … [L51078] In July 2024, the US FDA rejected the approval of insulin icodec, citing concerns regarding hypoglycemia and the indication being sought for type 1 diabetes mellitus.
Benzethonium
go.drugbank.com/drugs/DB11125ApprovedThere is evidence that benzethonium acts as a spermatocide but may cause vaginal irritation [A32304]. … Benzethonium was identified as a novel cancer-specific compound by cell-based small-molecule screen [A32298].
Mixtures: Tough Guy Hand Sanitizer Wipes Tough GuyProducts: Bob Barker Antibacterial un-wrapped bodyCefixime
go.drugbank.com/drugs/DB00671ApprovedInvestigational[L49293] The beta-lactam ring of cefixime inhibits bacterial cell wall synthesis by binding to the penicillin-binding proteins which will then result in lysis.
Products: Cefixime 400 mg UD, CEFIXIMA MK 20MG/MLSildenafil
go.drugbank.com/drugs/DB00203ApprovedInvestigationalNevertheless, it is because of this mechanism that sildenafil is also indicated for treating pulmonary arterial hypertension but is also additionally notorious for interacting with various anti-anginal … In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850
Products: VIATHER BY CORNEElasomeran
go.drugbank.com/drugs/DB15654ApprovedInvestigational[L39160, L39277] A similar booster dose is also available in the US for patients 18 years of age and older. … In clinical trials, there were no differences in the safety profiles between younger and older (65 years of age and older) study participants.
Ondansetron
go.drugbank.com/drugs/DB00904ApprovedInvestigationalWithdrawnHaving been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has demonstrated a long history of use and efficacy. … It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Products: Ondansetron Accord 2 mg/ml Injektions- oder InfusionslösungRivanicline
go.drugbank.com/drugs/DB05855ExperimentalIt was originally developed as a potential treatment for Alzheimer's disease for its nootropic effects but has also been found to inhibit the production of Interleukin-8.
Synonyms: (3E)-N-methyl-4-(pyridin-3-yl)but-3-en-1-amine