Search

Displaying results 251 - 260 of 10000 in total
  1. Drug

    Lovastatin

    go.drugbank.com/drugs/DB00227
    ApprovedInvestigational

    were found in clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels, while lovastatin has been found to have an average decrease in LDL-C of 25-40%. … [A174553] More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid

    Synonyms: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate, 6-alpha-methylcompactinCategories: Cytochrome P-450 Substrates, P-glycoprotein inhibitors
  2. Drug

    Normethadone

    go.drugbank.com/drugs/DB11609
    ApprovedIllicit

    Normethadone is used as an opioid antitussive in combination with [DB11610]. It is marketed in Canada by Valeant under the tradename Cophylac.

    Synonyms: 6-dimethylamino-4,4-diphenyl-3-hexanone, Isomethadone I
  3. Drug

    Balsalazide

    go.drugbank.com/drugs/DB01014
    Approved

    The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. It is usually administered as the disodium salt. … Mesalazine is also known as 5-aminosalicylic acid, or 5-ASA.

    Synonyms: 3-(2-{4-[(2-carboxyethyl)carbamoyl]phenyl}hydrazinylidene)-6-oxocyclohexa-1,4-diene-1-carboxylic acid, (E)-5-((4-(((2-carboxyethyl)amino)carbonyl)phenyl)azo)-2-hydroxybenzoic acidCategories: Non COX-2 selective NSAIDS
  4. Drug

    Amisometradine

    go.drugbank.com/drugs/DB19368
    ApprovedWithdrawn

    Synonyms: 2,4(1h,3h)-pyrimidinedione, 6-amino-3-methyl-1-(2-methyl-2-propenyl)-, 6-amino-3-methyl-1-(2-methylallyl)-2,4(1h,3h)-pyrimidinedione
  5. Drug

    Lumiracoxib

    go.drugbank.com/drugs/DB01283
    ApprovedWithdrawn

    Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). … New Zealand and Canada have also followed suit in recalling the drug.

    Synonyms: 2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acidCategories: COX-2 Inhibitors, Cytochrome P-450 Substrates
  6. Drug

    Megestrol

    go.drugbank.com/drugs/DB19378
    Approved

    Synonyms: 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione
  7. Drug

    Leflunomide

    go.drugbank.com/drugs/DB01097
    ApprovedInvestigational

    Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. … Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: 4-ISOXAZOLECARBOXAMIDE, 5-METHYL-N-(4-(TRIFLUOROMETHYL)PHENYL)-, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide
  8. Drug

    Anileridine

    go.drugbank.com/drugs/DB00913
    ApprovedIllicitWithdrawn

    Anileridine is a synthetic opioid and strong analgesic medication. It is a narcotic pain reliever used to treat moderate to severe pain. … Narcotic analgesics act in the central nervous system (CNS) to relieve pain. Some of their side effects are also caused by actions in the CNS.

    Synonyms: 1-[2-(4-aminophenyl)ethyl]-4-phenyl-4-piperidinecarboxlic acid ethyl ester, ethyl 1-(2-(4-aminophenyl)ethyl)-4-phenyl-4-piperidinecarboxylateCategories: Heterocyclic Compounds, 1-Ring
  9. Drug

    9-(6-deoxy-alpha-L-talofuranosyl)-6-methylpurine

    go.drugbank.com/drugs/DB02934
    Experimental

    Synonyms: 9-(6-deoxy-alpha-L-talofuranosyl)-6-methylpurine
  10. Drug

    Tipiracil

    go.drugbank.com/drugs/DB09343
    ApprovedInvestigational

    Tipiracil is a thymidine phosphorylase inhibitor. It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102. … The main function of Tipiracil in TAS-102 is to increase trifluridine bioavailability by inhibiting its catabolism.

    Synonyms: 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione, 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dioneMixtures: LONSURF FILM-COATED TABLET 15 MG/6.14 MG, LONSURF FILM-COATED TABLET 15 MG/6.14 MG