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Megestrol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Data Packages
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Identification

Generic Name
Megestrol
DrugBank Accession Number
DB19378
Background

Not Available

Type
Small Molecule
Groups
Approved
Structure
3D
Similar Structures
Weight
Average: 342.479
Monoisotopic: 342.219494826
Chemical Formula
C22H30O3
Synonyms
  • 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione
  • Chronopil
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
AProgesterone receptor
binder
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

ATC Codes
G03FB04 — Megestrol and estrogenG03DB02 — MegestrolG03FA08 — Megestrol and estrogenG03AC05 — MegestrolG03AA04 — Megestrol and ethinylestradiolL02AB01 — MegestrolG03AB01 — Megestrol and ethinylestradiol
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
EA6LD1M70M
CAS number
3562-63-8
InChI Key
VXIMPSPISRVBPZ-NWUMPJBXSA-N
InChI
InChI=1S/C22H30O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h11-12,16-18,25H,5-10H2,1-4H3/t16-,17+,18-,20-,21-,22+/m0/s1
IUPAC Name
SMILES
[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C=C(C)C2=CC(=O)CC[C@]12C

References

General References
Not Available
KEGG Compound
C07120
RxNav
6703
ChEBI
6722
ChEMBL
CHEMBL4071215
ZINC
ZINC000004097356
PharmGKB
PA450351
Wikipedia
Megestrol

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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2Active Not RecruitingTreatmentEndometrial Atypical Hyperplasia / Endometrial Carcinoma1somestatusstop reasonjust information to hide
2CompletedTreatmentEndometrial Carcinoma / Recurrent Uterine Corpus Carcinoma / Stage IIIA Uterine Corpus Cancer / Stage IIIB Uterine Corpus Cancer / Stage IIIC1 Uterine Corpus Cancer / Stage IIIC2 Uterine Corpus Cancer / Stage IVA Uterine Corpus Cancer / Stage IVB Uterine Corpus Cancer1somestatusstop reasonjust information to hide
2RecruitingPreventionEndometrial Atypical Hyperplasia /Endometrioid Intraepithelial Neoplasia / Endometrial Carcinoma1somestatusstop reasonjust information to hide
2TerminatedTreatmentHigh Grade Squamous Intraepithelial Neoplasia / Stage 0 Uterine Corpus Cancer1somestatusstop reasonjust information to hide
1, 2RecruitingTreatmentFIGO Grade 1 Endometrial Endometrioid Adenocarcinoma / FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma / Metastatic Endometrial Endometrioid Adenocarcinoma / Recurrent Endometrial Endometrioid Adenocarcinoma / Stage IV Uterine Corpus Cancer AJCC v81somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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Details1. Progesterone receptor
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Binder
General Function
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor
Specific Function
ATPase binding
Gene Name
PGR
Uniprot ID
P06401
Uniprot Name
Progesterone receptor
Molecular Weight
98979.96 Da
References
  1. Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]

Drug created at August 26, 2024 17:44 / Updated at October 06, 2024 11:29