Balsalazide is an aminosalicylate used to treat ulcerative colitis. Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease.
- Mechanism
- Curator reviewed
The mechanism of action of 5-aminosalicylic acid is unknown, but appears to exert its anti-inflammatory effects locally (in the GI tract) rather than systemically. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways (catalyzes the formation of prostaglandin precursors from arachidonic acid), and through the lipoxygenase pathways (catalyzes the formation of leukotrienes and hydroxyeicosatetraenoic acids from arachidonic acid and its metabolites), is increased in patients with chronic inflammatory bowel disease. Therefore, it is possible that 5-aminosalicylic acid diminishes inflammation by blocking production of arachidonic acid metabolites in the colon through both the inhibition of cyclooxygenase and lipoxygenase.
- Primary indication
- For the treatment of mildly to moderately active ulcerative colitis.Curator reviewed · 2 structured indications
- Formula / weight
- C17H15N3O6 · 357.3175 g/mol (avg)
- First approval
- United States, 2000
Resolves to
IPOKCKJONYRRHP-FMQUCBEESA-NSMILESOC(=O)CCNC(=O)C1=CC=C(C=C1)\N=N\C1=CC=C(O)C(=C1)C(O)=OWhat you can answer from here — as of September 12, 2026
Which drugs share a target with Balsalazide, and which of those have an active Phase 3 trial?
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