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Didanosine
go.drugbank.com/drugs/DB00900ApprovedInvestigationalThis modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. … Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative
Synonyms: 9-((2S,5R)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-olProducts: DIDANOSINA 400 MG, DIDAN 100 MG TABLETAFormestane
go.drugbank.com/drugs/DB08905ApprovedWithdrawnFormestane suppresses estrogen production from anabolic steroids or prohormones. … Some clinical data has suggested that the clinically recommended dose of 250mg was too low.
Synonyms: 4-OH-AIbrutinib
go.drugbank.com/drugs/DB09053ApprovedInvestigationalIbrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. … [A32299] Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval;[L12228] however, in
Products: IMBRUVICA 140 mg film-coated tablets, IMBRUVICA 280 mg film-coated tabletsTebipenem pivoxil
go.drugbank.com/drugs/DB16840Approvedlimited or no alternative oral treatment options. … tract infections generally required hospitalization, a PICC line, or infusion center visits.
Difluprednate
go.drugbank.com/drugs/DB06781ApprovedInvestigationalDifluprednate is abbreviated DFBA, or difluoroprednisolone butyrate acetate. It is indicated for treatment of endogenous anterior uveiti. … Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate.
Products: DİFLUNAT POMAT, 20 G, EPITOPIC POMAT %0,05, 20 GEtomidate
go.drugbank.com/drugs/DB00292ApprovedInvestigationalImidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
Products: ETOMIDATO 2 MG/ML, ETOMIDATE-LIPURO INJECTION 20 mg/10 mlPhosphatidyl serine
go.drugbank.com/drugs/DB00144ApprovedNutraceuticalIn apoptosis, phosphatidyl serine is transferred to the outer leaflet of the plasma membrane. This is part of the process by which the cell is targeted for phagocytosis. … Because of the potentail cognitive benefits of phosphatidylserine, the substance is sold as a dietary supplement to people who believe they can benefit from an increased intake.
Estradiol benzoate
go.drugbank.com/drugs/DB13953ApprovedVet approvedWithdrawnEster pro-drugs of estradiol are therefore considered to be bioidentical forms of estrogen [T84]. Estradiol benzoate is not currently available in Canada or the US. … Following absorption, the esters are cleaved, resulting in the release of endogenous estradiol, or 17β-estradiol.
Somatostatin
go.drugbank.com/drugs/DB09099ApprovedInvestigationalWithdrawnThe actions of somatostatin are mediated via signalling pathways of G protein-coupled somatostatin receptors. … [DB00104] is a long-acting analogue of somatostatin that inhibits the release of a number of hormones, and is clinically used to relieve symptoms of uncommon gastroenteropancreatic endocrine tumours, as
Products: STILAMIN 3000 FOR INJECTION 3 mg/ampoule, SOMATOSAN 3 MG IV INFUZYON ICIN 1 AMPULMecasermin
go.drugbank.com/drugs/DB01277ApprovedInvestigationalThe amino acid sequence of the product is identical to that of endogenous human IGF-1. … IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons.