Difluprednate is a topical corticosteroid used for the symptomatic treatment of inflammation and pain associated with ocular surgery. It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate.
- Mechanism
- Curator reviewed
Corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins (lipocortins). It is postulated that these proteins control the biosynthesis of potent mediators of infammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
- Primary indication
- For the treatment of inflammation and pain associated with ocular surgery.Curator reviewed · 6 structured indications
- Formula / weight
- C27H34F2O7 · 508.5515 g/mol (avg)
- First approval
- Canada, 2017 · United States, 2008
- Also known as
- DFBA · Difluoroprednisolone butyrate acetate
- Code names
- W-6309
- Brand names
Resolves to
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Which drugs share a target with Difluprednate, and which of those have an active Phase 3 trial?
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