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Dolutegravir
go.drugbank.com/drugs/DB08930ApprovedInvestigationalDolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). … [A7514] The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity.
Categories: Antivirals used in combination for the treatment of HIV infectionsYohimbine
go.drugbank.com/drugs/DB01392ApprovedInvestigationalVet approvedWithdrawnYohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Categories: Drugs Used in Erectile Dysfunction, Adrenergic alpha-2 Receptor AntagonistsCanagliflozin
go.drugbank.com/drugs/DB08907ApprovedInvestigationalIt was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 for a second indication of reducing the risk of cardiovascular events in patients diagnosed with type … Cardiovascular disease is the most common cause of death in these patients [A177083].
Categories: Drugs Used in DiabetesCelivarone
go.drugbank.com/drugs/DB16012InvestigationalCalibrator for the Maintenance of Sinus Rhythm in Patients With Recent Atrial Fibrillation/flutter). … Celivarone is under investigation in clinical trial NCT00233441 (Placebo Controlled Double-blind Dose Ranging Study of the Efficacy and Safety of SSR149744C 50, 100, 200 or 300 Mg OD With Amiodarone as
Burosumab
go.drugbank.com/drugs/DB14012ApprovedInvestigationalThe U.S. Food and Drug Administration approved Crysvita (burosumab) in April 2018. … Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic
Linagliptin
go.drugbank.com/drugs/DB08882ApprovedInvestigationalLinagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes [L9557]. … Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding[A37050
Categories: DPP-IV Inhibitors, Drugs Used in DiabetesAmphetamine
go.drugbank.com/drugs/DB00182ApprovedIllicitInvestigationalThis use derived into a large overproduction of amphetamine and all the surplus after the war finalized ended up in the black market, producing the initiation of the illicit abuse.[A18540] … [L5194] During World War II, amphetamine was used to promote wakefulness in the soldiers.
Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB14407ApprovedInvestigationalthat it was previously exposed to. … Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen
Mixtures: Efluelda Tetra Injektionssuspension in einer Fertigspritze, VAXİGRİP 0,5 ML IM/SC ENJEKSİYON İÇİN SÜSPANSİYON İÇEREN KULLANIMA HAZIR ENJEKTÖR , 10 ADETRecombinant stabilized RSV B prefusion F antigen
go.drugbank.com/drugs/DB18714ApprovedInvestigationalof an adjuvant. … [L49560] It is the first RSV vaccine approved for use in pregnant patients to prevent RSV in infants.[L49555]
Fosinopril
go.drugbank.com/drugs/DB00492ApprovedInvestigationalFosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals … It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).
Products: Ran-fosinopril