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Icatibant
go.drugbank.com/drugs/DB06196ApprovedInvestigational[A4017,A263041] It was investigated as a potential treatment of hereditary angioedema (HAE) as bradykinin was implicated in HAE swelling; specifically, mice lacking B<sub>2</sub> receptors showed reduced … [A4017,A263046] Icatibant was approved by the FDA on August 25, 2011, and by the EMA in 2008 as a treatment for hereditary angioedema.
Ascorbyl phosphate
go.drugbank.com/drugs/DB11352ApprovedInvestigationalWhile ascorbyl phosphate salts provide a constant delivery of vitamin C into the skin, they also mediate an antioxidant action to act as a free radical scavenger and increases collagen production *in vitro … As vitamin C is susceptible to breakdown of compound and discoloration in cosmetic formulations, ascorbyl phosphate, along with other Vitamin C derivatives, acts as an active and stable precursor of vitamin
Alkaline Phosphatase
go.drugbank.com/drugs/DB05768InvestigationalAlkaline Phosphatase (AP) is an oral treatment and has a very favorable side-effect profile. … AP only acts locally in the colon to reduce the continuous inflammation of the colon by endotoxin from Gram-negative bacteria and extracellular ATP in UC patients.
Coagulation Factor IX (Recombinant)
go.drugbank.com/drugs/DB00100Approvedmedium that is then processed and purified for use as a pharmaceutical agent. … Recombinant Coagulation Factor IX is a purified Factor IX glycoprotein produced by recombinant DNA technology.
Products: BENEFIX 1000 IU IV ENJEKSIYONLUK COZELTI ICIN TOZ VE COZUCU, BENEFIX 250 IU IV ENJEKSIYONLUK COZELTI ICIN TOZ VE COZUCU, 1 ADETEtesevimab
go.drugbank.com/drugs/DB15897InvestigationalEtesevimab (LY-CoV016, also known as JS016) is a fully human and recombinant monoclonal antibody that targets the SARS-CoV-2 surface spike protein receptor binding domain. … progressing to severe COVID-19:[L40179] this EUA later expanded in December 2021 to include all younger children at high risk, including newborns.
Tibolone
go.drugbank.com/drugs/DB09070ApprovedInvestigationalTibolone is a synthetic steroid hormone drug, which is mainly non-selective in its binding profile, acting as an agonist primarily at estrogen receptors (ER), with a preference for ER alpha [L1874]. … In June 2006, Organon Pharmaceuticals announced the receipt of a Not Approvable Letter from the U.S.
Hesperetin
go.drugbank.com/drugs/DB01094InvestigationalHesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesLodoxamide
go.drugbank.com/drugs/DB06794ApprovedLodoxamide is a mast-cell stabilizer for topical administration into the eye. … Mast-cell stabilizers, first one approved being cromolyn sodium, are used in treatment of ocular hypersensitivity reactions such as vernal conjunctivitis.
Temsirolimus
go.drugbank.com/drugs/DB06287ApprovedInvestigationalTemsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007. … Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: TORISEL 25 MG/ML IV INFUZYONLUK COZELTI ICEREN FLAKON, 1 ADETLoteprednol
go.drugbank.com/drugs/DB00873ApprovedInvestigationalWithdrawnLoteprednol is a corticosteroid. A more commonly used formulation of loteprednol is its ester, [loteprednol etabonate].