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Carvedilol
go.drugbank.com/drugs/DB01136ApprovedInvestigationalCarvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. … [L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the
Mixtures: Co-Dilatrend 25 mg/12,5 mg - Filmtabletten, CARIVALAN 25/5Categories: Heterocyclic Compounds, 3-Ring, Cytochrome P-450 SubstratesClozapine
go.drugbank.com/drugs/DB00363ApprovedInvestigationalClozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. … [L905] Due to its severe adverse effects profile, clozapine is only available through a restricted program under a Risk Evaluation Mitigation Strategy (REMS) called the Clozapine REMS Program.[L905]
Categories: Heterocyclic Compounds, 3-Ring, Serotonin 5-HT1 Receptor AntagonistsProducts: CLONEX 25 MG TABLET, 50 ADET, LEPONEX 25 MG TABLET, 50 ADETCholecalciferol
go.drugbank.com/drugs/DB00169ApprovedInvestigationalNutraceuticalVitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight [L5689]. … Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the
Synonyms: (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol, (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-olInternational brands: Delta-D, Micro-DCitalopram
go.drugbank.com/drugs/DB00215ApprovedInvestigationalIt is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs. … [A261316,A14720] Specifically, it has a very minimal effect on dopamine and norepinephrine transportation and virtually no affinity for muscarinic, histaminergic, or GABAergic receptors.
Mixtures: Sentralopram AM-10Categories: Serotonin 5-HT2 Receptor Antagonists, Cytochrome P-450 SubstratesMirabegron
go.drugbank.com/drugs/DB08893ApprovedInvestigationalMirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. … Mirabegron has a comparatively favorable adverse effect profile as compared to other available treatment options, and its complementary mechanism to the antimuscarinics that came before it allows for its
Categories: Adrenergic beta-3 Receptor Agonists, Selective Beta 3-adrenergic AgonistsProducts: BETMIGA 25 MG UZATILMIŞ SALIMLI FILM TABLET , TABLET, 30 ADET, Begamir 25 mg Uzatılmış Salımlı Film Kaplı Tablet (30 adet)Doxecitine
go.drugbank.com/drugs/DB02594ApprovedInvestigationalDoxecitine is a synthetic form of the naturally occurring pyrimidine deoxyribonucleoside deoxycytidine. … This combination is the first and only approved treatment for Thymidine Kinase 2 deficiency.[L54613, L54618]
Synonyms: MT-1621 COMPONENT 2'-DEOXYCYTIDINE, 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2- yl)pyrimidin-2(1H)-oneCategories: Heterocyclic Compounds, 1-RingLisdexamfetamine
go.drugbank.com/drugs/DB01255ApprovedInvestigationalLisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine,[A40246] covalently attached to the naturally occurring amino acid L-lysine.
Products: VYVANSE CAPSULES 50 mg, VYVANSE® 50 MG CAPSULASVericiguat
go.drugbank.com/drugs/DB15456ApprovedInvestigational[A227458,A227488] Cyclic GMP acts as a second messenger, activating a number of downstream signaling cascades that elicit a broad variety of effects, and these diverse cellular effects have implicated … [A227458] As a direct stimulator of sGC, vericiguat mitigates the need for a functional NO-sGC-cGMP axis and thereby helps to prevent the myocardial and vascular dysfunction associated with decreased sGC
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingProducts: VERQUVO 5 MG FİLM KAPLI TABLET , 14 ADET, VERQUVO 5 MG FİLM KAPLI TABLET , 28 ADETPoractant alfa
go.drugbank.com/drugs/DB09113ApprovedInvestigationaland SP-C). … Poractant alfa is a pulmonary surfactant marketed as Curosurf in the United States and Canada.
Products: CUROSURF 240 MG/3 ML INTRATRAKEAL SUSPANSIYON IÇEREN FLAKON, 1 ADET, CUROSURF 120 MG/1,5 ML INTRATRAKEAL SUSPANSIYON IÇEREN FLAKON, 1 ADETFusidic acid
go.drugbank.com/drugs/DB02703ApprovedInvestigationalAn antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis. It is often used topically in creams and eyedrops but is available in sys...
Mixtures: FUCICORT 20 MG/G + 1 MG/G KREM, 30 G, M-FURO FA %0.1 + %2 KREM, 30 GCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Inhibitors