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Glatiramer
go.drugbank.com/drugs/DB05259ApprovedInvestigational[A248870] Along with [human interferon beta], [teriflunomide], and [dimethyl fumarate], glatiramer acetate is a first-line drug for patients with MS. … [A248880] It was approved by the FDA in 1996, and a generic version became available in 2017.
Methylphenobarbital
go.drugbank.com/drugs/DB00849ApprovedIt has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital.
Ramipril
go.drugbank.com/drugs/DB00178ApprovedInvestigationalRamiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).
Categories: Antihypertensive Agents Indicated for HypertensionAsparagine
go.drugbank.com/drugs/DB00174ApprovedNutraceuticalWithdrawnIt is biosynthesized from aspartic acid and ammonia by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Colchicine
go.drugbank.com/drugs/DB01394ApprovedInvestigationalColchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus."[A183611] Its use was first approved by the FDA in 1961.
Categories: Experimental Unapproved Treatments for COVID-19Warfarin
go.drugbank.com/drugs/DB00682ApprovedInvestigationalWarfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors.
Categories: Vitamin K Inhibitors, Vitamin K AntagonistsPegulicianine
go.drugbank.com/drugs/DB18731ApprovedInvestigational[L50537] Pegulicianine (under the brand name Lumisight) was approved for use by the FDA in April 2024.[L50537,L50547] It received Fast Track and priority review for this indication.[L50547] … Pegulicianine is an optical imaging agent indicated for fluorescence imaging in patients with breast cancer.
Categories: Compounds used in a research, industrial, or household settingGrazoprevir
go.drugbank.com/drugs/DB11575ApprovedApproved in January 2016 by the FDA, Zepatier is indicated for the treatment of HCV genotypes 1 and 4 with or without [DB00811] depending on the the presence of resistance associated amino acid substitutions … Grazoprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotypes 1 and 4 [synthesis].
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseCarbidopa
go.drugbank.com/drugs/DB00190ApprovedInvestigational[L5110] On the other hand, the combination treatment of carbidopa/levodopa was originally developed by Watson Labs but the historical information by the FDA brings back to the approval of this combination … therapy developed by Mayne Pharma in 1992.
Mixtures: LEVOCAENT OR 100/25/200, LEVOCAENT OR 100/25/200