DB00849ApprovedSmall molecule
A barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital.
- Mechanism
- Curator reviewed
Methylphenobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
- Primary indication
- For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy.Curator reviewed
- Formula / weight
- C13H14N2O3 · 246.2619 g/mol (avg)
- Also known as
- 1-Methylphenobarbital · Enphenemal · Mephobarbital · Mephobarbitone · Methylphenobarbitone
Resolves to
Clinical / RWD
Structure
InChIKey
ALARQZQTBTVLJV-UHFFFAOYSA-NSMILESCCC1(C(=O)NC(=O)N(C)C1=O)C1=CC=CC=C1What you can answer from here — as of September 12, 2026
11Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Methylphenobarbital, and which of those have an active Phase 3 trial?
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