Amcinonide is a topical corticosteroid used in the treatment of inflammation and pruritus due to a variety of dermatoses. A medication applied to the skin that helps relieve redness, itchiness and other symptoms of inflammation caused by many skin conditions.
- Mechanism
- Curator reviewed
The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Amcinonide has affinity for the glucocorticoid receptor. It has weak affinity for the progesterone receptor, and virtually no affinity for the mineralocorticoid, estrogen, or androgen receptors.
- Primary indication
- For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.Curator reviewed · 2 structured indications
- Formula / weight
- C28H35FO7 · 502.5717 g/mol (avg)
- First approval
- Canada, 2005 · United States, 1999
- Also known as
- Triamcinolonacetatcyclopentanonid
- Code names
- CL-34699
Resolves to
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Which drugs share a target with Amcinonide, and which of those have an active Phase 3 trial?
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