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Defibrotide
go.drugbank.com/drugs/DB04932ApprovedInvestigationalIt has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). … Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA.
Categories: Blood and Blood Forming Organs, Nucleic Acids, Nucleotides, and NucleosidesFinafloxacin
go.drugbank.com/drugs/DB09047ApprovedWithdrawnFinafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December 2014. … Finafloxacin is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus.
IL15-NK Cell
go.drugbank.com/drugs/DB15725InvestigationalIn particular, incubation with IL-15 allows NK cells to lyse a broad range of fresh and cultured tumor targets that the cell is not normally sensitive to. … Natural killer (NK) cells can be incubated with ‘feeder cells’ expressing certain cytokines prior to maturation to enhance their activity.
Synonyms: IL15-NK CellUmbralisib
go.drugbank.com/drugs/DB14989ApprovedInvestigationalWithdrawn[A229363] Follicular lymphoma is also treated with rituximab and other chemotherapeutic agents, but may show similar progression. … from clinical trials.
Categories: Antineoplastic and Immunomodulating AgentsTocopherol
go.drugbank.com/drugs/DB11251ApprovedInvestigationalTocopherol exists in four different forms designated as α, β, δ, and γ. They present strong antioxidant activities, and it is determined as the major form of vitamin E. … When the carbons at position 5- and 7- are not methylated, they can function as electrophilic centers that can trap reactive oxygen and nitrogen species.
Mixtures: MultiVitamin Drops with Fluoride and IronCategories: Alimentary Tract and Metabolism, Diet, Food, and NutritionSorbitol
go.drugbank.com/drugs/DB01638ApprovedInvestigationalSorbitol occurs naturally and is also produced synthetically from glucose. … It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures.
Mixtures: Cleanse Gut And Colon, INFUSOL M20S (Mannitol 17.5%w/v and Sorbitol 2.5%w/v Intravenous Infusion)Categories: Indicators and Reagents, Diet, Food, and NutritionAAV9/MFSD8
go.drugbank.com/drugs/DB18616ExperimentalAAV9/MFSD8 is a gene therapy developed by Neurogene Inc. … It is an adeno-associated virus serotype 9 (AAV9) vector with an engineered transgene encoding the human CLN7/MFSD8 gene for expression of active human major facilitator superfamily domain containing 8
Synonyms: An adeno-associated virus serotype 9 (AAV9) vector with engineered transgene encoding the human CLN7/MFSD8 gene for expression of active human major facilitator superfamily domain containing 8Phendimetrazine
go.drugbank.com/drugs/DB01579ApprovedIllicitPhendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970.
Fidaxomicin
go.drugbank.com/drugs/DB08874ApprovedInvestigational[A190492] The antibacterial activity of fidaxomicin is distinct from macrolides and rifamycins, as the bactericidal activity is time-dependent, and not concentration-dependent. … [L11575] Fidaxomicin is a naturally-occurring 18-member macrocycle derived from fermentation.
Categories: Alimentary Tract and MetabolismPariglasgene brecaparvovec
go.drugbank.com/drugs/DB16801Approved[L64050,L64051] The approval covers adults and pediatric patients 8 years of age and older and was based on a statistically significant reduction in daily cornstarch intake, a surrogate endpoint, with … Pariglasgene brecaparvovec-opnr is an adeno-associated virus serotype 8 (AAV8)–based gene therapy for glycogen storage disease type Ia (GSDIa), a disorder caused by deficiency of the enzyme glucose-6-phosphatase
Categories: Cellular and Gene Therapy