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Ustekinumab
go.drugbank.com/drugs/DB05679ApprovedInvestigational[A187349] It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. … In October 2019, it was also approved by the FDA for use to manage moderately to severely active ulcerative colitis in adults.
Categories: Biologics for psoriasis treatmentProducts: STELARA CONCENTRATE FOR SOLUTION FOR INFUSION 130MG/26ML, STELARA 130mg/26mL Concentrate for Solution for InfusionRisankizumab
go.drugbank.com/drugs/DB14762ApprovedInvestigationalRisankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). … [L39885,L44191,L44231] Risankizumab is being investigated for atopic dermatitis.[A254716]
Products: SKYRIZI SOLUTION FOR INJECTION IN PRE-FILLED PEN 150MG/ML, SKYRIZI SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 75MG/0.83MLTriptorelin
go.drugbank.com/drugs/DB06825ApprovedInvestigationalVet approvedSerum testosterone concentrations may fall to levels typically observed in surgically castrated men.
Categories: Gonadotropin Releasing Hormone Receptor Agonist, Gonadotropin Releasing Hormone Receptor AgonistsProducts: Salvacyl 11,25 mg Pulver und Lösungsmittel zur Herstellung einer Depot-Injektionssuspension, Pamorelin LA 22,5 mg Pulver und Lösungsmittel zur Herstellung einer Depot-InjektionssuspensionDenosumab
go.drugbank.com/drugs/DB06643ApprovedInvestigational; Both biosimilars also received marketing authorization in the EU in May 2024. … for fracture receiving adjuvant aromatase inhibitor therapy for breast cancer in September 2011 and in men with osteoporosis at high risk for fracture in September 2012.
Categories: Drugs for Treatment of Bone DiseasesProducts: XGEVA 120mg Solution for Injection, XGEVA Solution for Injection 120 mg/vialBenralizumab
go.drugbank.com/drugs/DB12023ApprovedInvestigationalIt is an afucosylated IgG which gives it high affinity for the FcγRIIIα receptor in natural killer cells, macrophages and neutrophils. … Benralizumab is a humanized recombinant monoclonal antibody of the isotype IgG1k immunoglobulin that specifically binds to the alpha chain of the interleukin 5 receptor (IL-5R) expressed on eosinophils
Categories: Drugs for Obstructive Airway Diseases, Interleukin-5 Receptor alpha-directed Cytolytic AntibodyProducts: Fasenra 30 mg solution for injection in pre-filled syringe, Fasenra 30mg Solution for Injection in Pre-filled PenDorzolamide
go.drugbank.com/drugs/DB00869ApprovedInvestigational[L11377] It works by blocking an enzyme in the ciliary process that regulates ion balance and fluid pressure in the eyes. … [A1304] First marketed in 1995,[A190624] dorzolamide is available in ophthalmic solutions as monotherapy marketed as Trusopt [L11377] or in combination with [timolol] as Cosopt PF.[L11380]
Mixtures: Van-dorzolamide-timolol, Cosopt PFCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesTirzepatide
go.drugbank.com/drugs/DB15171ApprovedInvestigational[A246265] Tirzepatide was approved by the FDA on May 13, 2022, under the brand name MOUNJARO by the FDA for the treatment of adults with type 2 diabetes, making it the first and only GIP and GLP-1 receptor … agonist for this indication.
Categories: Glucose-dependent Insulinotropic Polypeptide Receptor AgonistProducts: Mounjaro 5 mg solution for injection in vial, Mounjaro 10 mg solution for injection in vialMitomycin
go.drugbank.com/drugs/DB00305ApprovedInvestigational[A193419] Mitomycin's cross-linking activity has resulted in its approval for the treatment of a variety of cancers - the most recent of which is an April 2020 approval for its use in low-grade Upper … Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.
Products: MITONCO 10mg powder for solution for injection/infusion or intravesical, Mitomycin for InjectionCefepime
go.drugbank.com/drugs/DB01413ApprovedInvestigational[A249050] In general, cefepime seems to be well tolerated; however, patients treated with this antibiotic, especially those with renal impairment, may develop neurotoxicity.[A249050,L42095,L42100] … [A2457,A249050] Cefepime is normally used to treat severe nosocomial pneumonia and infections caused by multi-resistant microorganisms such as _Pseudomonas aeruginosa_, and is also indicated for the empirical
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseProducts: Cefepim Sandoz 1 g - Pulver zur Herstellung einer Injektions-/Infusionslösung, Cefepim Sandoz 2 g - Pulver zur Herstellung einer Injektions-/InfusionslösungMethotrexate
go.drugbank.com/drugs/DB00563ApprovedInvestigationalMethotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. … [A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: EMTHEXATE PF, EMTHEXATE PF 25 MG/ML