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Tacrolimus
go.drugbank.com/drugs/DB00864ApprovedInvestigationalTacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. … It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: Qvaya 1 mg/ml Emulsion zur Anwendung auf der Haut, PROGRAF® XL CAPSULAS DE LIBERACIONPROLONGADA DE 1 MGTolcapone
go.drugbank.com/drugs/DB00323ApprovedInvestigationalWithdrawnTolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. … It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity.
International brands: Sen De NingProducts: TASMAR ROCHE TABLETA LACADA DE 100 MG, TASMAR ROCHE TABLETAS LACADAS DE 200 MGEphedra sinica root
go.drugbank.com/drugs/DB01363ApprovedNutraceuticalThe sale of ephedra-containing supplements intended to increase muscle weight or promote weight loss was banned in the United States in 2004 due to the risk for adverse effects and a lack of evidence for … Ephedra is an alkaloid chemical compound traditionally obtained from the plant _Ephedra sinica_.
Mixtures: Dr. Miller's Formula No. 1Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesQuetiapine
go.drugbank.com/drugs/DB01224ApprovedInvestigational[L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. … It is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [clozapine] and [olanzapine].[A2189]
Categories: Dopamine D2 Receptor Antagonists, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: Nu-quetiapine, QUETIAPINA DR. REDDY'STenofovir disoproxil
go.drugbank.com/drugs/DB00300ApprovedInvestigationalTenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase … This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
Mixtures: INMUNOVIR DUO, Ag-emtricitabine / Tenofovir Disoproxil FumarateCategories: Antivirals used in combination for the treatment of HIV infectionsCetylpyridinium
go.drugbank.com/drugs/DB11073ApprovedInvestigationalIts salt form, cetylpyridinium chloride, is typically found as an active ingredient in mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays. … Cetylpyridinium is a quaternary ammonium with broad-spectrum antiseptic properties.
Mixtures: Kank-A, NORAVER P TABLETAS DE DISOLUCIÓN BUCALCategories: Compounds used in a research, industrial, or household settingPovidone-iodine
go.drugbank.com/drugs/DB06812ApprovedInvestigationalPovidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. … This unique complex was discovered in 1955 at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski.
Mixtures: D-Care 100X, Point Of Care Kit KMCategories: Compounds used in a research, industrial, or household settingColistimethate
go.drugbank.com/drugs/DB01111ApprovedInvestigationalVet approvedColistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa. … Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms.
Products: COLIMYCIN 1.150.000 IU IM/IV ENJEKSIYON IÇIN LIYOFILIZE TOZ IÇEREN FLAKON, 1 ADET, LIXICOL 1.500.000 IU IM/IV ENJEKSIYON ICIN LIYOFIZE TOZ ICEREN FLAKON, 1 ADETMeloxicam
go.drugbank.com/drugs/DB00814ApprovedInvestigationalVet approvedIt is a preferential COX-2 inhibitor, purportedly reducing the risk of adverse gastrointestinal tract effects, however, this is a topic of controversy.[A190198,A190201] … Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis.
Mixtures: OCAM® DUO., MELOCAM DUO 15/20 TABLETASProducts: Nu-meloxicam, MEL- OD 15Paliperidone
go.drugbank.com/drugs/DB01267ApprovedInvestigationalIt has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. … Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug.
Categories: Dopamine D2 Receptor Antagonists, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: INVEGA SUSTENNA® SUSPENSIÓN DE LIBERACIÓN PROLONGADA DE 25MG, INVEGASUSTENNA® SUSPENSIÓN DE LIBERACIÓN PROLONGADA DE 75 MG