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Benzyl alcohol
go.drugbank.com/drugs/DB06770ApprovedInvestigationalMixtures: Hand SanitizerCategories: Scabicides, Insecticides and Repellents, Antiparasitic Products, Insecticides and RepellentsEslicarbazepine acetate
go.drugbank.com/drugs/DB09119ApprovedInvestigationalEslicarbazepine's mechanism of action is not well understood, but it is known that it does exert anticonvulsant activity by inhibiting repeated neuronal firing and stabilizing the inactivated state of … Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled
Categories: Eslicarbazepine and prodrugsPralidoxime
go.drugbank.com/drugs/DB00733ApprovedInvestigationalVet approvedPralidoxime is an antidote to organophosphate pesticides and chemicals. … If given within 24 hours,after organophosphate exposure, pralidoxime reactivates the enzyme cholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase
Mixtures: ATNAA atropine and pralidoxime chloride Auto-InjectorCategories: pralidoxime and atropineRopeginterferon alfa-2b
go.drugbank.com/drugs/DB15119ApprovedInvestigational[A242005] Ropeginterferon alfa-2b is a next-generation mono-pegylated type I interferon produced from proline-IFN-α-2b in _Escherichia coli_ that has high tolerability and a long half-life. … [A242000, A242005] [Interferon alfa-2b] has been used for decades to treat PV but requires frequent dosing and is not tolerated by all patients.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsCinnamaldehyde
go.drugbank.com/drugs/DB14184ApprovedIt occurs naturally in the bark of cinnamon trees and other species of the genus Cinnamomum such as camphor and cassia. Sensitivity to cinnamaldehyde may be identified with a clinical patch test. … Cinnamaldehyde is a naturally occurring flavonoid that gives the spice cinnamon its flavour and odour.
Categories: Diet, Food, and NutritionEflornithine
go.drugbank.com/drugs/DB06243ApprovedInvestigationalWithdrawn[A262839] In 1960 and 2000, the FDA approved eflornithine under the brand names ORNIDYL and VANIQUA for the treatment of African trypanosomiasis and hirsutism, respectively, but has since been discontinued … This approval is based on positive results obtained from a multi-site, single-arm, externally controlled study of children with high-risk neuroblastoma, where a 52% reduction in the risk of relapse and
Categories: Skin and Mucous Membrane Agents, Amino Acids, Peptides, and ProteinsLumacaftor
go.drugbank.com/drugs/DB09280ApprovedInvestigational[A20343] Improvements in lung function (ppFEV1) were found to be statistically significant, but minimal, with only a 2.6-3.0% change from baseline with more than 70% of patients failing to achieve an absolute … Ivacaftor is manufactured and distributed by Vertex Pharmaceuticals.
Categories: ivacaftor and lumacaftorNADPH oxidase organizer 1
go.drugbank.com/bio_entities/BE0002423TargetHumansConstitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the … Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity
Synonyms: SH3 and PX domain-containing protein 5Kinesin-like protein KIF1A
go.drugbank.com/bio_entities/BE0003115TargetHumansThe interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites … Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons.
Synonyms: Unc-104- and KIF1A-related proteinSerine/threonine-protein kinase DCLK1
go.drugbank.com/bio_entities/BE0009429TargetHumansProbable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system
Synonyms: Doublecortin-like and CAM kinase-like 1