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Fruquintinib
go.drugbank.com/drugs/DB11679ApprovedInvestigationalThe first approach can be exemplified by [bevacizumab], a VEGF-A trap antibody. … [A262102,A262107] Indeed, oncogenic activation, loss of tumor suppressor function, and hypoxia, usually facilitated by cancer cells, are known to upregulate VEGF.
Sonrotoclax
go.drugbank.com/drugs/DB18753ApprovedInvestigationalIt promotes tumor cell survival by sequestering proapoptotic proteins and blocking the intrinsic mitochondrial apoptotic pathway.
Equilin
go.drugbank.com/drugs/DB02187ExperimentalAn estrogenic steroid produced by horses. It has a total of four double bonds in the A- and B-ring. High concentration of equilin is found in the urine of pregnant mares.
Thioproperazine
go.drugbank.com/drugs/DB01622ApprovedThioproperazine is a potent neuroleptic with antipsychotic properties. Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually ...
P-113D
go.drugbank.com/drugs/DB04987ExperimentalIt is being pursued as a potential treatment for cystic fibrosis by Demegen, Inc.
Clomethiazole
go.drugbank.com/drugs/DB06470InvestigationalIt is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant.
Talopram
go.drugbank.com/drugs/DB09190ExperimentalIt was researched in the 1960s and 1970s but never marketed.
Demegestone
go.drugbank.com/drugs/DB13857ExperimentalIt was previously marketed in France as Lutionex, but has since been discontinued.
Bupranolol
go.drugbank.com/drugs/DB08808ExperimentalIt does not have intrinsic sympathomimetic activity (ISA), but does have strong membrane stabilizing activity.
Besifovir dipivoxil
go.drugbank.com/drugs/DB05020InvestigationalBesifovir dipivoxil is believed to inhibit viral proliferation by interrupting the replicating machinery of the virus.